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法国的处方类阿片类药物与经济困难。

Prescription opioids and economic hardship in France.

机构信息

Université Libre de Bruxelles, Avenue F. D. Roosevelt, 50, 1050, Brussels, Belgium.

European Center for Advanced Research in Economics and Statistics (ECARES), Université Libre de Bruxelles, Brussels, Belgium.

出版信息

Eur J Health Econ. 2023 Dec;24(9):1473-1504. doi: 10.1007/s10198-022-01557-4. Epub 2023 Jan 30.

DOI:10.1007/s10198-022-01557-4
PMID:36710287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9884604/
Abstract

This paper studies how opioid analgesic sales are empirically related to socioeconomic disparities in France, with a focus on poverty. This analysis is made possible using the OpenHealth database, which provides retail sales data for opioid analgesics available on the French market. We exploit firm-level data for each of the 94 departments in Metropolitan France between 2008 and 2017. We show that increases in the poverty rate are associated with increases in sales: a one percentage point increase in poverty is associated with approximately a 5% increase in mild opioid sales. Our analysis further shows that opioid sales are positively related to the share of middle-aged people and individuals with basic education only, while they are negatively related to population density. The granularity and longitudinal nature of these data allow us to control for a large pool of potential confounding factors. Our results suggest that additional interventions should be more intensively addressed toward the most deprived areas. We conclude that a combination of policies aimed at improving economic prospects and strictly monitoring access to opioid medications would be beneficial for reducing opioid-related harm.

摘要

本文研究了阿片类镇痛药的销售情况与法国社会经济差距(尤其是贫困问题)之间的实证关系。这项分析是利用 OpenHealth 数据库完成的,该数据库提供了法国市场上可获得的阿片类镇痛药的零售销售数据。我们利用了 2008 年至 2017 年法国本土 94 个部门的每家公司的数据。结果表明,贫困率的上升与销售的增加有关:贫困率增加一个百分点,轻度阿片类药物的销售额就会增加约 5%。我们的分析进一步表明,阿片类药物的销售与中年人口和仅有基础教育的个体比例呈正相关,而与人口密度呈负相关。这些数据的粒度和纵向性质使我们能够控制大量潜在的混杂因素。我们的研究结果表明,应更加集中地向最贫困地区提供额外的干预措施。我们的结论是,结合旨在改善经济前景和严格监控阿片类药物获取的政策将有利于减少与阿片类药物相关的危害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/10550883/7bf60be2c841/10198_2022_1557_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/10550883/f3d971bc3c3e/10198_2022_1557_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/10550883/bcbb5fed23b0/10198_2022_1557_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/10550883/08567cff8724/10198_2022_1557_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/10550883/7bf60be2c841/10198_2022_1557_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/10550883/f3d971bc3c3e/10198_2022_1557_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/10550883/bcbb5fed23b0/10198_2022_1557_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/10550883/08567cff8724/10198_2022_1557_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ff1/10550883/7bf60be2c841/10198_2022_1557_Fig4_HTML.jpg

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本文引用的文献

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Death by Robots? Automation and Working-Age Mortality in the United States.机器人导致的死亡?美国的自动化与劳动年龄人口死亡率。
Demography. 2022 Apr 1;59(2):607-628. doi: 10.1215/00703370-9774819.
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Social vulnerabilities for substance use: Stressors, socially toxic environments, and discrimination and racism.
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Neuropharmacology. 2021 May 1;188:108518. doi: 10.1016/j.neuropharm.2021.108518. Epub 2021 Mar 11.
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COVID-19 and the role of inequality in French regional departments.COVID-19 与法国各地区不平等现象的关系。
Eur J Health Econ. 2021 Mar;22(2):311-327. doi: 10.1007/s10198-020-01254-0. Epub 2021 Jan 2.
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The Opioid Epidemic During the COVID-19 Pandemic.新冠疫情期间的阿片类药物流行情况
JAMA. 2020 Oct 27;324(16):1615-1617. doi: 10.1001/jama.2020.18543.
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How French general practitioners respond to declining medical density: a study on prescription practices, with an insight into opioids use.法国全科医生如何应对医疗密度下降:一项关于处方实践的研究,深入探讨了阿片类药物的使用情况。
Eur J Health Econ. 2020 Dec;21(9):1391-1398. doi: 10.1007/s10198-020-01222-8. Epub 2020 Aug 3.
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