Ozer Tugba, Henry Charles S
Department of Bioengineering, Faculty of Chemical-Metallurgical Engineering, Yildiz Technical University, 34220, Istanbul, Türkiye.
Health Biotechnology Joint Research and Application Center of Excellence, 34220, Esenler, Istanbul, Türkiye.
Curr Top Med Chem. 2024;24(11):952-972. doi: 10.2174/0115680266286981240207053402.
An individual's therapeutic drug exposure level is directly linked to corresponding clinical effects. Rapid, sensitive, inexpensive, portable and reliable devices are needed for diagnosis related to drug exposure, treatment, and prognosis of diseases. Electrochemical sensors are useful for drug monitoring due to their high sensitivity and fast response time. Also, they can be combined with portable signal read-out devices for point-of-care applications. In recent years, nanomaterials such as carbon-based, carbon-metal nanocomposites, noble nanomaterials have been widely used to modify electrode surfaces due to their outstanding features including catalytic abilities, conductivity, chemical stability, biocompatibility for development of electrochemical sensors. This review paper presents the most recent advances about nanomaterials-based electrochemical sensors including the use of green assessment approach for detection of drugs including anticancer, antiviral, anti-inflammatory, and antibiotics covering the period from 2019 to 2023. The sensor characteristics such as analyte interactions, fabrication, sensitivity, and selectivity are also discussed. In addition, the current challenges and potential future directions of the field are highlighted.
个体的治疗药物暴露水平与相应的临床效果直接相关。对于与药物暴露、疾病治疗和预后相关的诊断，需要快速、灵敏、廉价、便携且可靠的设备。电化学传感器因其高灵敏度和快速响应时间而可用于药物监测。此外，它们可与便携式信号读出设备结合用于即时护理应用。近年来，碳基、碳-金属纳米复合材料、贵金属纳米材料等纳米材料因其包括催化能力、导电性、化学稳定性、生物相容性等突出特性，被广泛用于修饰电极表面以开发电化学传感器。本文综述了2019年至2023年期间基于纳米材料的电化学传感器的最新进展，包括使用绿色评估方法检测抗癌、抗病毒、抗炎和抗生素等药物。还讨论了传感器的特性，如分析物相互作用、制备、灵敏度和选择性。此外，还强调了该领域当前面临的挑战和潜在的未来发展方向。
