一名青春期女孩前臂出现孤立性结节的原发性皮肤滤泡中心淋巴瘤：病例报告及文献复习
Primary Cutaneous Follicle Center Lymphoma Presenting as a Solitary Nodule on the Forearm of an Adolescent Girl: A Case Report and Literature Review.
作者信息
Al Harbi Sadan Mohammed, Al Natour Sahar, Al Saif Nasser Mohammed, Al Saif Noura, Al Bayat Methal Isam
机构信息
Department of Dermatology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
出版信息
Clin Cosmet Investig Dermatol. 2023 Jan 20;16:167-172. doi: 10.2147/CCID.S396326. eCollection 2023.
Primary cutaneous B-cell lymphomas (PCBCLs) are very rare to be seen in pediatric and adolescent age group, especially primary cutaneous follicle center lymphoma (PCFCL) which is considered the least occurring main subtype. Here, we describe a 16-year-old girl who developed a slowly growing solitary firm smooth surfaced erythematous nodule over her forearm. Histopathological examination showed a dense dermal nodular, periadnexal and perivascular lymphoid infiltrate extending deep to the subcutis. Immunohistochemical staining showed a B-cell population with positivity for CD20, variable staining for BCL6 and CD10 and uniquely staining for BCL2. Although a primary cutaneous marginal zone lymphoma (PCMZL) was considered but the presences of interfollicular BCL6 and CD10 positivity established the diagnosis of PCFCL. To our knowledge, only 12 cases of pediatric and adolescent PCFCL have been described in the literature.
原发性皮肤B细胞淋巴瘤（PCBCLs）在儿童和青少年年龄组中极为罕见，尤其是原发性皮肤滤泡中心淋巴瘤（PCFCL），它被认为是最不常见的主要亚型。在此，我们描述一名16岁女孩，她在前臂出现了一个生长缓慢的孤立性坚实、表面光滑的红斑结节。组织病理学检查显示真皮内有密集的结节状、腺周和血管周围淋巴样浸润，延伸至皮下深处。免疫组织化学染色显示B细胞群CD20阳性，BCL6和CD10染色可变，BCL2呈独特染色。虽然曾考虑为原发性皮肤边缘区淋巴瘤（PCMZL），但滤泡间BCL6和CD10阳性确诊为PCFCL。据我们所知，文献中仅描述了12例儿童和青少年PCFCL病例。
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