脑出血的体外模型
In vitro models of intracerebral hemorrhage.
作者信息
Syed Bilal, Nirwane Abhijit, Yao Yao
机构信息
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, 33612, USA.
出版信息
Brain Hemorrhages. 2022 Sep;3(3):105-107. doi: 10.1016/j.hest.2022.06.002. Epub 2022 Jun 16.
Abstract
Intracerebral hemorrhage (ICH) is a severe clinical emergency caused by bleeding into brain parenchyma. Currently, there are no effective treatments to improve ICH outcomes. Developing new therapies for ICH relies on a thorough understanding of ICH pathophysiology and good in vitro models that enable mechanistic research. In this review, we summarized widely used in vitro ICH models and compared their advantages and disadvantages. Next, key questions that need to be answered in future research are discussed. We aim to provide a quick reference/summary of widely used in vitro ICH models and stimulate the development of new ICH models.
摘要
脑出血（ICH）是一种因脑实质内出血而引发的严重临床急症。目前，尚无有效的治疗方法来改善脑出血的预后。开发针对脑出血的新疗法依赖于对脑出血病理生理学的透彻理解以及有助于进行机制研究的良好体外模型。在本综述中，我们总结了广泛使用的体外脑出血模型，并比较了它们的优缺点。接下来，讨论了未来研究中需要回答的关键问题。我们旨在提供广泛使用的体外脑出血模型的快速参考/总结，并推动新型脑出血模型的开发。
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