Urrea Carlos Ramos, Pedroso Amanda Paula, Thomazini Fernanda, do Carmo Andreia Cristina Feitosa, Telles Mônica Marques, Sawaya Ana Lydia, Franco Maria do Carmo Pinho, Ribeiro Eliane Beraldi
Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Escola Paulista de Medicina, Campus São Paulo Library, Universidade Federal de São Paulo, São Paulo, Brazil.
Front Nutr. 2023 Jan 13;9:1040167. doi: 10.3389/fnut.2022.1040167. eCollection 2022.
Thyroid hormones exert multiple physiological effects essential to the maintenance of basal metabolic rate (BMR), adaptive thermogenesis, fat metabolism, growth, and appetite. The links between obesity and the hormones of the thyroid axis, i.e., triiodothyronine (T3), thyroxine (T4), and thyrotropin (TSH), are still controversial, especially when considering children and adolescents. This population has high rates of overweight and obesity and several treatment approaches, including nutritional, psychological, and physical exercise interventions have been used. Understanding the importance of the hormones of the thyroid axis in the recovery from overweight and obesity may help directing measures to the maintenance of a healthy body composition. The present scoping review was carried out to analyze studies evaluating these hormonal levels throughout interventions directed at treating overweight and obesity in children and adolescents. The main purpose was to ascertain whether the hormones levels vary during weight loss.
We selected for analysis 19 studies published between 1999 and 2022.
Most of the studies showed that changes in different anthropometric indicators, in response to the multidisciplinary interventions, correlated positively with free T3 (fT3), total T3 (TT3), and TSH. With respect to free T4 (fT4) and total T4 (TT4).
The most common finding was of unchanged levels and, hence, no significant association with weight loss. Moreover, thyroxine supplementation has failed to affect the response to the interventions. Further studies are necessary to elucidate the relevance of the variations in hormone levels to the establishment of overweight/obesity and to the recovery from these conditions in children/adolescents.
https://www.crd.york.ac.uk/prospero/, identifier CRD42020203359.
甲状腺激素发挥着多种生理作用，对维持基础代谢率（BMR）、适应性产热、脂肪代谢、生长和食欲至关重要。肥胖与甲状腺轴激素（即三碘甲状腺原氨酸（T3）、甲状腺素（T4）和促甲状腺激素（TSH））之间的联系仍存在争议，尤其是在儿童和青少年中。这一人群超重和肥胖率较高，并且已经采用了多种治疗方法，包括营养、心理和体育锻炼干预措施。了解甲状腺轴激素在超重和肥胖恢复过程中的重要性，可能有助于指导维持健康身体成分的措施。本综述旨在分析评估针对儿童和青少年超重和肥胖干预过程中这些激素水平的研究。主要目的是确定减肥期间激素水平是否会发生变化。
我们选择分析了1999年至2022年间发表的19项研究。
大多数研究表明，多学科干预后不同人体测量指标的变化与游离T3（fT3）、总T3（TT3）和TSH呈正相关。关于游离T4（fT4）和总T4（TT4）。
最常见的发现是水平未发生变化，因此与体重减轻无显著关联。此外，补充甲状腺素未能影响对干预措施的反应。需要进一步研究以阐明激素水平变化与儿童/青少年超重/肥胖的发生以及从这些状况中恢复的相关性。
