Fu Jing, Zhang Lin, An Yu, Duan Yan, Liu Jia, Wang Guang
Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (mainland).
Department of Endocrinology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing, China (mainland).
Med Sci Monit. 2021 Mar 19;27:e930865. doi: 10.12659/MSM.930865.
BACKGROUND Obesity can influence thyroid function through multiple routes, even in people who are euthyroid. The correlation between weight and thyroid function is a matter of debate. The present study investigated the relationship between body weight and thyroid function in euthyroid Chinese adults. MATERIAL AND METHODS A total of 1564 participants with serum thyrotropin (TSH) and thyroid hormone levels within the reference range were included. All of them were tested for thyroid function parameters and categorized, based on body mass index (BMI), into 3 groups: normal weight, overweight, and obese. The effects of BMI on thyroid function were examined using linear (continuous values) and logistic (dichotomous levels according to medians or means) regression and controlling for age and sex. RESULTS There were significant differences in free triiodothyronine (FT3) levels and FT3/free thyroxine (FT4) ratios among participants who were normal weight, overweight, and obese (both P<0.001). Multivariable regression analysis (P<0.001) showed that BMI was positively associated with FT3 levels and FT3/FT4 ratios. Compared with the normal weight group, the patients who were overweight or obese had significantly higher FT3 levels and FT3/FT4 ratios that were higher than average, according to logistic regression analyses. CONCLUSIONS We found that Chinese adults who are obese may have higher FT3 levels and FT3/FT4 ratios than those who are of normal weight, even if their thyroid function values are within the normal range.
肥胖可通过多种途径影响甲状腺功能,即使在甲状腺功能正常的人群中也是如此。体重与甲状腺功能之间的相关性存在争议。本研究调查了甲状腺功能正常的中国成年人的体重与甲状腺功能之间的关系。
共纳入1564名血清促甲状腺激素(TSH)和甲状腺激素水平在参考范围内的参与者。对所有参与者进行甲状腺功能参数检测,并根据体重指数(BMI)分为3组:正常体重、超重和肥胖。使用线性(连续值)和逻辑(根据中位数或均值的二分水平)回归分析,并控制年龄和性别,研究BMI对甲状腺功能的影响。
正常体重、超重和肥胖参与者的游离三碘甲状腺原氨酸(FT3)水平和FT3/游离甲状腺素(FT4)比值存在显著差异(均P<0.001)。多变量回归分析(P<0.001)显示,BMI与FT3水平和FT3/FT4比值呈正相关。根据逻辑回归分析,与正常体重组相比,超重或肥胖患者的FT3水平显著更高,且FT3/FT4比值高于平均水平。
我们发现,即使甲状腺功能值在正常范围内,肥胖的中国成年人的FT3水平和FT3/FT4比值可能高于正常体重的成年人。