Suppr超能文献

正常甲状腺功能的中国成年人身体质量指数与甲状腺功能之间的关联

Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults.

作者信息

Fu Jing, Zhang Lin, An Yu, Duan Yan, Liu Jia, Wang Guang

机构信息

Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China (mainland).

Department of Endocrinology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing, China (mainland).

出版信息

Med Sci Monit. 2021 Mar 19;27:e930865. doi: 10.12659/MSM.930865.

Abstract

BACKGROUND Obesity can influence thyroid function through multiple routes, even in people who are euthyroid. The correlation between weight and thyroid function is a matter of debate. The present study investigated the relationship between body weight and thyroid function in euthyroid Chinese adults. MATERIAL AND METHODS A total of 1564 participants with serum thyrotropin (TSH) and thyroid hormone levels within the reference range were included. All of them were tested for thyroid function parameters and categorized, based on body mass index (BMI), into 3 groups: normal weight, overweight, and obese. The effects of BMI on thyroid function were examined using linear (continuous values) and logistic (dichotomous levels according to medians or means) regression and controlling for age and sex. RESULTS There were significant differences in free triiodothyronine (FT3) levels and FT3/free thyroxine (FT4) ratios among participants who were normal weight, overweight, and obese (both P<0.001). Multivariable regression analysis (P<0.001) showed that BMI was positively associated with FT3 levels and FT3/FT4 ratios. Compared with the normal weight group, the patients who were overweight or obese had significantly higher FT3 levels and FT3/FT4 ratios that were higher than average, according to logistic regression analyses. CONCLUSIONS We found that Chinese adults who are obese may have higher FT3 levels and FT3/FT4 ratios than those who are of normal weight, even if their thyroid function values are within the normal range.

摘要

背景

肥胖可通过多种途径影响甲状腺功能,即使在甲状腺功能正常的人群中也是如此。体重与甲状腺功能之间的相关性存在争议。本研究调查了甲状腺功能正常的中国成年人的体重与甲状腺功能之间的关系。

材料与方法

共纳入1564名血清促甲状腺激素(TSH)和甲状腺激素水平在参考范围内的参与者。对所有参与者进行甲状腺功能参数检测,并根据体重指数(BMI)分为3组:正常体重、超重和肥胖。使用线性(连续值)和逻辑(根据中位数或均值的二分水平)回归分析,并控制年龄和性别,研究BMI对甲状腺功能的影响。

结果

正常体重、超重和肥胖参与者的游离三碘甲状腺原氨酸(FT3)水平和FT3/游离甲状腺素(FT4)比值存在显著差异(均P<0.001)。多变量回归分析(P<0.001)显示,BMI与FT3水平和FT3/FT4比值呈正相关。根据逻辑回归分析,与正常体重组相比,超重或肥胖患者的FT3水平显著更高,且FT3/FT4比值高于平均水平。

结论

我们发现,即使甲状腺功能值在正常范围内,肥胖的中国成年人的FT3水平和FT3/FT4比值可能高于正常体重的成年人。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6fe/7986724/3146a3247892/medscimonit-27-e930865-g001.jpg

相似文献

1
Association Between Body Mass Index and Thyroid Function in Euthyroid Chinese Adults.
Med Sci Monit. 2021 Mar 19;27:e930865. doi: 10.12659/MSM.930865.
2
Thyroid function, body mass index, and metabolic risk markers in euthyroid adults: a cohort study.
BMC Endocr Disord. 2019 Jun 7;19(1):58. doi: 10.1186/s12902-019-0383-2.
4
Association of thyroid function with sarcopenia in elderly Chinese euthyroid subjects.
Aging Clin Exp Res. 2019 Aug;31(8):1113-1120. doi: 10.1007/s40520-018-1057-z. Epub 2018 Oct 26.
5
Associations Between Thyroid Hormones Within the Euthyroid Range and Indices of Obesity in Obese Chinese Women of Reproductive Age.
Metab Syndr Relat Disord. 2019 Oct;17(8):416-422. doi: 10.1089/met.2019.0036. Epub 2019 Jul 29.
7
Relationship between thyroid function and elevated blood pressure in euthyroid adults.
J Clin Hypertens (Greenwich). 2018 Oct;20(10):1541-1549. doi: 10.1111/jch.13369. Epub 2018 Sep 8.

引用本文的文献

1
Association of Gene Polymorphisms with Body Mass Index in Hashimoto's Thyroiditis.
Int J Mol Sci. 2025 Apr 12;26(8):3667. doi: 10.3390/ijms26083667.
2
Increased thyroxine levels of patients with allergic rhinitis.
Sci Rep. 2025 Jan 21;15(1):2667. doi: 10.1038/s41598-025-85762-0.
3
The association of thyroid stimulating hormone and body fat in adults.
PLoS One. 2024 Dec 3;19(12):e0314704. doi: 10.1371/journal.pone.0314704. eCollection 2024.
4
The association between serum soluble α-Klotho and thyroid profile among adults from NHANES 2007-2012.
BMC Endocr Disord. 2024 Aug 28;24(1):161. doi: 10.1186/s12902-024-01687-1.
6
Association between the Systemic Immune-Inflammation Index and Thyroid Function in U.S. Adults.
Mediators Inflamm. 2023 Nov 16;2023:5831858. doi: 10.1155/2023/5831858. eCollection 2023.
8
Circulating free T3 associates longitudinally with cardio-metabolic risk factors in euthyroid children with higher TSH.
Front Endocrinol (Lausanne). 2023 May 17;14:1172720. doi: 10.3389/fendo.2023.1172720. eCollection 2023.
9
Thyroid axis hormones and anthropometric recovery of children/adolescents with overweight/obesity: A scoping review.
Front Nutr. 2023 Jan 13;9:1040167. doi: 10.3389/fnut.2022.1040167. eCollection 2022.

本文引用的文献

1
A Mechanism Exploration of Metabolic Syndrome Causing Nodular Thyroid Disease.
Int J Endocrinol. 2019 Nov 26;2019:9376768. doi: 10.1155/2019/9376768. eCollection 2019.
2
Thyroid function, body mass index, and metabolic risk markers in euthyroid adults: a cohort study.
BMC Endocr Disord. 2019 Jun 7;19(1):58. doi: 10.1186/s12902-019-0383-2.
4
Guideline Recommendations for Obesity Management.
Med Clin North Am. 2018 Jan;102(1):49-63. doi: 10.1016/j.mcna.2017.08.006.
5
Comparing the diagnostic ability of inflammatory markers in metabolic syndrome.
Clin Chim Acta. 2017 Dec;475:1-6. doi: 10.1016/j.cca.2017.09.023. Epub 2017 Sep 30.
6
Thyroid Function in Human Obesity: Underlying Mechanisms.
Horm Metab Res. 2016 Dec;48(12):787-794. doi: 10.1055/s-0042-121421. Epub 2016 Dec 6.
7
Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans.
Physiol Rev. 2016 Oct;96(4):1169-209. doi: 10.1152/physrev.00032.2015. Epub 2016 Aug 3.
8
Indices of adiposity and thyroid hormones in euthyroid postmenopausal women.
Eur J Endocrinol. 2015 Aug;173(2):237-45. doi: 10.1530/EJE-15-0141.
9
Increased TSH in obesity: Evidence for a BMI-independent association with leptin.
Diabetes Metab. 2015 Jun;41(3):248-51. doi: 10.1016/j.diabet.2014.11.009. Epub 2014 Dec 22.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验