Fouad R, Ali Amira A M
Department of Chemistry, Faculty of Education, Ain Shams University Roxy Cairo Egypt
RSC Adv. 2023 Jan 11;13(3):1883-1891. doi: 10.1039/d2ra06052c. eCollection 2023 Jan 6.
The current study represents the successful fabrication and characterization of a Sm(iii) nano complex based on 2-cyano-'-((4-oxo-4-chromen-3-yl)methylene)acetohydrazide (CCMA). The fibrous Sm(iii) nanocomplex has been fabricated by the electrospinning technique. SEM analysis of the electrospun fibers has revealed that the fibers have a uniform structure and smooth surface without observing Sm(iii) nanocomplex crystals, the Sm(iii) nanocomplex has been well incorporated into the fibers. antitumor activity against two carcinogenic cell lines (HepG-2 and E.A.C.) as well as toxicity of pure Sm(iii) nanocomplex and its electrospun fibers have been detected. The biological results have shown that there is a significant antitumor activity with low toxicity of the pure Sm(iii) nanocomplex and its electrospun fibers with respect to different standard antitumor drugs. Also, the electrospun fibers recorded higher cytotoxicity (IC = 0.1 μM (Hep-G); 0.09 μM (E.A.C)) and lower toxicity (LD = 350 mg kg) than the pure ones. The release rate of the Sm(iii) nanocomplex from electrospun fibers has also been detected. The results have shown that the burst releasing of the Sm(iii) nanocomplex is about 22% after 1 h at the beginning, then a cumulative release increased gradually over the following hours. All results demonstrate the potential use of the Sm(iii) nanocomplex as a potent antitumor drug and its electrospun fibers as superior drug carriers for the treatment of tumors.
当前的研究展示了基于2-氰基-'-((4-氧代-4-色烯-3-基)亚甲基)乙酰肼(CCMA)成功制备和表征的Sm(iii)纳米复合物。通过静电纺丝技术制备了纤维状的Sm(iii)纳米复合物。对静电纺丝纤维的扫描电子显微镜(SEM)分析表明，纤维结构均匀，表面光滑，未观察到Sm(iii)纳米复合物晶体，Sm(iii)纳米复合物已很好地掺入纤维中。检测了其对两种致癌细胞系(HepG-2和E.A.C.)的抗肿瘤活性以及纯Sm(iii)纳米复合物及其静电纺丝纤维的毒性。生物学结果表明，相对于不同的标准抗肿瘤药物，纯Sm(iii)纳米复合物及其静电纺丝纤维具有显著的抗肿瘤活性且毒性较低。此外，静电纺丝纤维的细胞毒性更高(IC = 0.1 μM (Hep-G); 0.09 μM (E.A.C.))，毒性更低(LD = 350 mg/kg)。还检测了Sm(iii)纳米复合物从静电纺丝纤维中的释放速率。结果表明，Sm(iii)纳米复合物在开始1小时后的突发释放约为22%，随后在接下来的几个小时内累积释放逐渐增加。所有结果都证明了Sm(iii)纳米复合物作为一种有效的抗肿瘤药物及其静电纺丝纤维作为治疗肿瘤的优质药物载体的潜在用途。
