Zhou Kai, Hu Bingjie, Zhao Xinzhuan, Chi Hongbo, Pan Juan, Zheng Yufen, Bi Xiaojie, Chen Mengyuan, Xie Jicheng, Xu Jiaqin, Tung Tao-Hsin, Shen Bo, Zhu Hongguo
Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
Evidence-based Medicine Center, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Zhejiang, China.
Front Microbiol. 2023 Jan 13;13:1037733. doi: 10.3389/fmicb.2022.1037733. eCollection 2022.
In 2022, a new coronavirus variant (Omicron) infection epidemic broke out in Shanghai, China. However, it is unclear whether the duration of this omicron variant is different from that of the prototype strain.
We retrospectively analyzed 157 cases of Omicron variant infection in Taizhou Public Health Center from March 29, 2022, to April 18, 2022, and observed the dynamics of nucleic acid Ct values during the admission and discharge of patients. Clinical and laboratory indicators of these patients were also obtained.
Compared to the prototype strain, the Omicron variant showed a broad population susceptibility in infected individuals (regardless of age and presence of underlying disease) and had slight damage to the immune system and renal function; the viral loads peaked was 2-3 days from disease onset; the median duration of omicron variant was 15-18 days; the nucleic acid Ct value of nasopharyngeal swabs of infected patients is lower than that of throat swabs, and the Ct value of oropharyngeal swabs is unstable during the recovery period.
Therefore, we found that the time to peak viral load of this Omicron variant was 2-3 days after the onset of the disease, and the duration was 15-18 days; symptomatic patients had higher viral load and longer hospitalization time. This finding will provide a basis for understanding omicron variants and formulating the national prevention and control strategy.
2022年，中国上海爆发了新型冠状病毒变异株（奥密克戎）感染疫情。然而，尚不清楚该奥密克戎变异株的病程是否与原型毒株不同。
我们回顾性分析了2022年3月29日至2022年4月18日在台州市公共卫生中心收治的157例奥密克戎变异株感染病例，观察患者入院及出院期间核酸Ct值的动态变化。同时获取这些患者的临床和实验室指标。
与原型毒株相比，奥密克戎变异株在感染个体中表现出广泛的人群易感性（无论年龄及是否存在基础疾病），对免疫系统和肾功能有轻微损害；病毒载量在发病后2至3天达到峰值；奥密克戎变异株的病程中位数为15至18天；感染患者鼻咽拭子的核酸Ct值低于咽拭子，口咽拭子Ct值在恢复期不稳定。
因此，我们发现该奥密克戎变异株病毒载量达到峰值的时间为发病后2至3天，病程为15至18天；有症状患者的病毒载量更高，住院时间更长。这一发现将为了解奥密克戎变异株及制定国家防控策略提供依据。
