脓毒症中的内皮细胞代谢
Endothelial cell metabolism in sepsis.
作者信息
Wei Jue-Xian, Jiang Hui-Lin, Chen Xiao-Hui
机构信息
Emergency Department, the Second Affi liated Hospital, Guangzhou Medical University, Guangzhou 510260, China.
出版信息
World J Emerg Med. 2023;14(1):10-16. doi: 10.5847/wjem.j.1920-8642.2023.019.
BACKGROUND
Endothelial dysfunction in sepsis is a pathophysiological feature of septic organ failure. Endothelial cells (ECs) exhibit specific metabolic traits and release metabolites to adapt to the septic state in the blood to maintain vascular homeostasis.
METHODS
Web of Science and PubMed were searched from inception to October 1, 2022. The search was limited to the English language only. Two reviewers independently identified studies related to EC metabolism in sepsis. The exclusion criteria were duplicate articles according to multiple search criteria.
RESULTS
Sixty articles were included, and most of them were cell and animal studies. These studies reported the role of glycolysis, oxidative phosphorylation, fatty acid metabolism, and amino acid metabolism in EC homeostasis. including glycolysis, oxidative phosphorylation, fatty acid metabolism and amino acid metabolism. However, dysregulation of EC metabolism can contribute to sepsis progression.
CONCLUSION
There are few clinical studies on EC metabolism in sepsis. Related research mainly focuses on basic research, but some scientific problems have also been clarified. Therefore, this review may provide an overall comprehension and novel aspects of EC metabolism in sepsis.
背景
脓毒症中的内皮功能障碍是脓毒症器官衰竭的病理生理特征。内皮细胞（ECs）表现出特定的代谢特征并释放代谢产物，以适应血液中的脓毒症状态，维持血管稳态。
方法
检索了从创刊到2022年10月1日的Web of Science和PubMed。检索仅限于英文文献。两名 reviewers 独立确定了与脓毒症中EC代谢相关的研究。排除标准为根据多个检索标准判定的重复文章。
结果
纳入了60篇文章，其中大部分是细胞和动物研究。这些研究报道了糖酵解、氧化磷酸化、脂肪酸代谢和氨基酸代谢在EC稳态中的作用。包括糖酵解、氧化磷酸化、脂肪酸代谢和氨基酸代谢。然而，EC代谢失调会导致脓毒症进展。
结论
关于脓毒症中EC代谢的临床研究较少。相关研究主要集中在基础研究，但也澄清了一些科学问题。因此，本综述可能会提供对脓毒症中EC代谢的全面理解和新的视角。
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