Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa.
Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa; Iowa Neuroscience Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Transl Res. 2021 Aug;234:1-19. doi: 10.1016/j.trsl.2021.03.008. Epub 2021 Mar 13.
It is essential that safe and effective treatment options be available to patients suffering from chronic pain. The emergence of an opioid epidemic has shaped public opinions and created stigmas surrounding the use of opioids for the management of pain. This reality, coupled with high risk of adverse effects from chronic opioid use, has led chronic pain patients and their healthcare providers to utilize nonopioid treatment approaches. In this review, we will explore a number of cellular reorganizations that are associated with the development and progression of chronic pain. We will also discuss the safety and efficacy of opioid and nonopioid treatment options for chronic pain. Finally, we will review the evidence for adenylyl cyclase type 1 (AC1) as a novel target for the treatment of chronic pain.
对于患有慢性疼痛的患者来说，获得安全有效的治疗选择至关重要。阿片类药物流行的出现改变了公众的意见，并对阿片类药物治疗疼痛的使用产生了污名。这种现实情况，加上慢性阿片类药物使用的不良反应风险高，导致慢性疼痛患者及其医疗保健提供者转而使用非阿片类药物治疗方法。在本次综述中，我们将探讨与慢性疼痛的发展和进展相关的多种细胞重组。我们还将讨论阿片类药物和非阿片类药物治疗慢性疼痛的安全性和有效性。最后，我们将回顾环磷酸腺苷酶 1（AC1）作为治疗慢性疼痛的新靶点的证据。
