Pan Feixia, Xu Weize, Ding Jieying, Wang Chencen
Department of Cardiac Surgery, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Department of Pharmacy, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Front Cell Neurosci. 2023 Jan 11;16:1067570. doi: 10.3389/fncel.2022.1067570. eCollection 2022.
Hemorrhagic stroke is a devastating cerebrovascular disease with high morbidity and mortality, for which effective therapies are currently unavailable. Based on different bleeding sites, hemorrhagic stroke can be generally divided into intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), whose pathogenesis share some similarity. Ferroptosis is a recently defined programmed cell deaths (PCDs), which is a critical supplement to the hypothesis on the mechanism of nervous system injury after hemorrhagic stroke. Ferroptosis is characterized by distinctive morphological changes of mitochondria and iron-dependent accumulation of lipid peroxides. Moreover, scientists have successfully demonstrated the involvement of ferroptosis in animal models of ICH and SAH, indicating that ferroptosis is a promising target for hemorrhagic stroke therapy. However, the studies on ferroptosis still faces a serious of technical and theoretical challenges. This review systematically elaborates the role of ferroptosis in the pathogenesis of hemorrhagic stroke and puts forward some opinions on the dilemma of ferroptosis research.
出血性中风是一种具有高发病率和死亡率的毁灭性脑血管疾病，目前尚无有效的治疗方法。根据出血部位的不同，出血性中风通常可分为脑出血（ICH）和蛛网膜下腔出血（SAH），它们的发病机制有一些相似之处。铁死亡是最近定义的一种程序性细胞死亡（PCD），是出血性中风后神经系统损伤机制假说的重要补充。铁死亡的特征是线粒体的独特形态变化和脂质过氧化物的铁依赖性积累。此外，科学家已经成功证明铁死亡参与了脑出血和蛛网膜下腔出血的动物模型，这表明铁死亡是出血性中风治疗的一个有前景的靶点。然而，关于铁死亡的研究仍然面临一系列技术和理论挑战。本文综述系统阐述了铁死亡在出血性中风发病机制中的作用，并对铁死亡研究的困境提出了一些看法。
