铁死亡作为炎症相关性肠道疾病的治疗靶点。
Ferroptosis as a therapeutic target for inflammation-related intestinal diseases.
作者信息
Zhang Xiaoli, Ma Yiming, Lv Guoqing, Wang Hongying
机构信息
State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing, China.
出版信息
Front Pharmacol. 2023 Jan 13;14:1095366. doi: 10.3389/fphar.2023.1095366. eCollection 2023.
Ferroptosis is an iron-dependent programmed cell death characterized by reactive oxygen species-induced lipid peroxidation and resultant membrane damage. Recent research has elucidated the mechanism of ferroptosis and investigated the relationship between ferroptosis and various diseases, including degenerative diseases, cancer, and inflammation. Ferroptosis is associated with inflammation-related intestinal diseases such as colitis and colitis-associated cancer. New insights into the role of ferroptosis in the pathogenesis of inflammation-related gut diseases have suggested novel therapeutic targets. In this review, we summarize current information on the molecular mechanisms of ferroptosis and describe its emerging role and therapeutic potential in inflammation-related intestinal diseases.
铁死亡是一种铁依赖性程序性细胞死亡，其特征在于活性氧诱导的脂质过氧化和由此导致的膜损伤。最近的研究阐明了铁死亡的机制，并研究了铁死亡与各种疾病之间的关系，包括退行性疾病、癌症和炎症。铁死亡与炎症相关的肠道疾病如结肠炎和结肠炎相关癌症有关。对铁死亡在炎症相关肠道疾病发病机制中作用的新见解提示了新的治疗靶点。在这篇综述中，我们总结了关于铁死亡分子机制的当前信息，并描述了其在炎症相关肠道疾病中的新作用和治疗潜力。
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