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人参皂苷生物合成的基因与调控机制

Genes and Regulatory Mechanisms for Ginsenoside Biosynthesis.

作者信息

Mohanan Padmanaban, Yang Tae-Jin, Song Young Hun

机构信息

Plant Genomics and Breeding Research Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea.

Department of Agriculture, Forestry and Bioresources, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea.

出版信息

J Plant Biol. 2023;66(1):87-97. doi: 10.1007/s12374-023-09384-7. Epub 2023 Jan 21.

DOI:10.1007/s12374-023-09384-7
PMID:36714200
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9867542/
Abstract

is a medicinal plant belonging to the Araliaceae family. Ginseng is known as the king of oriental medicine, which has been practiced since ancient times in East Asian countries and globally in the modern era. Ginseng is used as an adaptogen, and research shows that it has several pharmacological benefits for various ailments such as cancer, inflammation, diabetes, and neurological symptoms. The pharmacological benefits of ginseng are attributed to the triterpenoid saponin ginsenosides found throughout the species, which are abundant in its root and are found exclusively in and . Recently, with the completion of the entire ginseng genome sequencing and the construction of the ginseng genome database, it has become possible to access information about many genes newly predicted to be involved in ginsenoside biosynthesis. This review briefly summarizes the current progress in ginseng genome analysis and genes involved in ginsenoside biosynthesis, proposing directions for functional studies of the predicted genes related to ginsenoside production and its regulation.

摘要

是一种属于五加科的药用植物。人参被誉为东方医学之王,自古以来就在东亚国家使用,在现代则在全球范围内使用。人参被用作适应原,研究表明它对癌症、炎症、糖尿病和神经症状等各种疾病有多种药理益处。人参的药理益处归因于整个物种中发现的三萜皂苷人参皂苷,其在根部含量丰富,且仅在[具体植物名称1]和[具体植物名称2]中发现。最近,随着人参全基因组测序的完成和人参基因组数据库的构建,获取有关许多新预测参与人参皂苷生物合成的基因的信息成为可能。本综述简要总结了人参基因组分析和参与人参皂苷生物合成的基因的当前进展,为人参皂苷生产及其调控相关预测基因的功能研究提出了方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755f/9867542/7d1e8b7e73dd/12374_2023_9384_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755f/9867542/887976a0d663/12374_2023_9384_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755f/9867542/7d1e8b7e73dd/12374_2023_9384_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755f/9867542/887976a0d663/12374_2023_9384_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755f/9867542/7d1e8b7e73dd/12374_2023_9384_Fig2_HTML.jpg

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本文引用的文献

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Preparation and pharmacological effects of minor ginsenoside nanoparticles: a review.人参二醇型皂苷纳米颗粒的制备及其药理作用:综述
Front Pharmacol. 2022 Aug 8;13:974274. doi: 10.3389/fphar.2022.974274. eCollection 2022.
2
Modification of ginsenoside saponin composition via the CRISPR/Cas9-mediated knockout of protopanaxadiol 6-hydroxylase gene in .通过CRISPR/Cas9介导的原人参二醇6-羟化酶基因敲除对人参皂苷皂苷成分进行修饰
J Ginseng Res. 2022 Jul;46(4):505-514. doi: 10.1016/j.jgr.2021.06.004. Epub 2021 Jun 18.
3
The dehiscence process in seeds and the stigmasterol biosynthesis pathway in terms of metabolomics.
19种五加科植物中三萜皂苷生物合成基因的系统发育分析及表达模式
Int J Mol Sci. 2025 Apr 7;26(7):3439. doi: 10.3390/ijms26073439.
4
MicroRNA-mediated regulation of ginsenoside biosynthesis in and its biotechnological implications.MicroRNA介导的人参皂苷生物合成调控及其生物技术意义。
Sci Prog. 2025 Apr-Jun;108(2):368504251332109. doi: 10.1177/00368504251332109. Epub 2025 Mar 31.
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Comparison of the Transformation Ability of the Major Saponins in by Enzyme and Commercial -glucosidase.酶与商业β-葡萄糖苷酶对[具体物质]中主要皂苷转化能力的比较
Microorganisms. 2025 Feb 23;13(3):495. doi: 10.3390/microorganisms13030495.
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Chemical and Transcriptomic Analyses Provide New Insights into Key Genes for Ginsenoside Biosynthesis in the Rhizome of C. A. Meyer.化学和转录组分析为 C. A. Meyer 根茎中人参皂苷生物合成的关键基因提供了新的见解。
Molecules. 2024 Oct 18;29(20):4936. doi: 10.3390/molecules29204936.
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Optimization of saponin extraction from the leaves of and and evaluation of their antioxidant, antihypertensive, hypoglycemic and anti-inflammatory activities.从[植物名称]叶片中提取皂苷的工艺优化及其抗氧化、降压、降糖和抗炎活性评价。 需注意,原文中“and”前后的植物名称缺失,以上是按照完整语义的翻译,实际翻译时应补充完整植物名。
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