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人参皂苷生物合成的基因与调控机制

Genes and Regulatory Mechanisms for Ginsenoside Biosynthesis.

作者信息

Mohanan Padmanaban, Yang Tae-Jin, Song Young Hun

机构信息

Plant Genomics and Breeding Research Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea.

Department of Agriculture, Forestry and Bioresources, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826 Korea.

出版信息

J Plant Biol. 2023;66(1):87-97. doi: 10.1007/s12374-023-09384-7. Epub 2023 Jan 21.

Abstract

is a medicinal plant belonging to the Araliaceae family. Ginseng is known as the king of oriental medicine, which has been practiced since ancient times in East Asian countries and globally in the modern era. Ginseng is used as an adaptogen, and research shows that it has several pharmacological benefits for various ailments such as cancer, inflammation, diabetes, and neurological symptoms. The pharmacological benefits of ginseng are attributed to the triterpenoid saponin ginsenosides found throughout the species, which are abundant in its root and are found exclusively in and . Recently, with the completion of the entire ginseng genome sequencing and the construction of the ginseng genome database, it has become possible to access information about many genes newly predicted to be involved in ginsenoside biosynthesis. This review briefly summarizes the current progress in ginseng genome analysis and genes involved in ginsenoside biosynthesis, proposing directions for functional studies of the predicted genes related to ginsenoside production and its regulation.

摘要

是一种属于五加科的药用植物。人参被誉为东方医学之王,自古以来就在东亚国家使用,在现代则在全球范围内使用。人参被用作适应原,研究表明它对癌症、炎症、糖尿病和神经症状等各种疾病有多种药理益处。人参的药理益处归因于整个物种中发现的三萜皂苷人参皂苷,其在根部含量丰富,且仅在[具体植物名称1]和[具体植物名称2]中发现。最近,随着人参全基因组测序的完成和人参基因组数据库的构建,获取有关许多新预测参与人参皂苷生物合成的基因的信息成为可能。本综述简要总结了人参基因组分析和参与人参皂苷生物合成的基因的当前进展,为人参皂苷生产及其调控相关预测基因的功能研究提出了方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/755f/9867542/887976a0d663/12374_2023_9384_Fig1_HTML.jpg

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