El-Shobokshy Set A, Abo-Samaha Magda I, El-Maksoud Eman M Abd, Khatab Shymaa A, Khafaga Asmaa F, Wirtu Gemechu
Department of Nutrition and Veterinary Clinical Nutrition, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
Poultry Breeding and Production, Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.
J Adv Vet Anim Res. 2022 Dec 31;9(4):743-753. doi: 10.5455/javar.2022.i644. eCollection 2022 Dec.
The study aimed to determine how Nano-Methionine (Nano-Meth) affected growth, lipid metabolism, and relative gene expression for acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), growth hormone receptor (GHR), insulin-like growth factor receptor-1 (IGFR-1), myostatin (MSTN), and cholecystokinin (CCK) genes in broiler chickens.
A total of 100 1-day-old broilers were randomly assigned into 2 groups: 1) the control group received drinking water without any supplements, and 2) the Nano-Meth group received 10 ml/l of 5% Nano-Meth starting from 1 day old until 35 days old (the end of the experiment).
Nano-Meth improved final body weight, weight gains, feed intake, and feed conversion ratio. Compared to the control group, Nano-Meth significantly lowered the serum levels of triglyceride, cholesterol, very low-density lipoprotein, and low-density lipoprotein in chickens. Nano-Meth significantly increased the serum levels of total protein, albumin, high-density lipoprotein, and glucose more than the control group. Nano-Meth lowered the mRNA gene expression of ACC, FAS, MSTN, and CCK but increased that of GHR and IGFR-1.
We concluded that supplementation with Nano-Meth enhances growth performance and decreases lipid accumulation in broiler chickens.
本研究旨在确定纳米蛋氨酸（Nano-Meth）如何影响肉鸡的生长、脂质代谢以及乙酰辅酶A羧化酶（ACC）、脂肪酸合酶（FAS）、生长激素受体（GHR）、胰岛素样生长因子受体-1（IGFR-1）、肌肉生长抑制素（MSTN）和胆囊收缩素（CCK）基因的相对基因表达。
总共100只1日龄肉鸡被随机分为2组：1）对照组饮用不添加任何补充剂的水，2）纳米蛋氨酸组从1日龄至35日龄（实验结束）饮用10毫升/升的5%纳米蛋氨酸溶液。
纳米蛋氨酸提高了最终体重、增重、采食量和饲料转化率。与对照组相比，纳米蛋氨酸显著降低了鸡血清中甘油三酯、胆固醇、极低密度脂蛋白和低密度脂蛋白的水平。纳米蛋氨酸显著提高了血清中总蛋白、白蛋白、高密度脂蛋白和葡萄糖的水平，且高于对照组。纳米蛋氨酸降低了ACC、FAS、MSTN和CCK的mRNA基因表达，但提高了GHR和IGFR-1的表达。
我们得出结论，补充纳米蛋氨酸可提高肉鸡的生长性能并减少脂质积累。
