Zhang Wei, Li Jingji, Silveira Camila P, Cai Qi, Dawson Kenneth A, Cagney Gerard, Yan Yan
Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, Guangdong, P.R. China.
Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.
PNAS Nexus. 2022 Aug 27;1(4):pgac172. doi: 10.1093/pnasnexus/pgac172. eCollection 2022 Sep.
Recent observations suggest a role for complex nanoscale particulate shape in the regulation of specific immune-related cellular and in vivo processes. We suspect that cellular recognition of nanostructure architecture could involve nonmolecular inputs, including cellular transduction of nanoscale spatially resolved stresses induced by complex shape. Here, we report nanoscale shape-dependent control of the cellular epigenome. Interpretation of ChIP-Seq sequencing suggests that differential marking of H3K27me3 may be linked to sensory and synapse-recognition of nanoscale forces induced by complex shape. The observations raise significant questions on the role of particle-shape-induced immune regulation and memory, with potential consequences in both causes and treatment of immune-related disease.
最近的观察结果表明，复杂的纳米级颗粒形状在特定免疫相关细胞和体内过程的调节中发挥作用。我们怀疑细胞对纳米结构架构的识别可能涉及非分子输入，包括由复杂形状诱导的纳米级空间分辨应力的细胞转导。在此，我们报告了细胞表观基因组的纳米级形状依赖性控制。ChIP-Seq测序的解释表明，H3K27me3的差异标记可能与复杂形状诱导的纳米级力的感觉和突触识别有关。这些观察结果对颗粒形状诱导的免疫调节和记忆的作用提出了重大问题，在免疫相关疾病的病因和治疗方面都可能产生潜在影响。
