Department of Virology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 26 G. Bonchev Str., 1113 Sofia, Bulgaria.
Antiviral Res. 2011 Feb;89(2):174-81. doi: 10.1016/j.antiviral.2010.11.014. Epub 2010 Dec 4.
The effects of combinations of three nonahydroxyterphenoyl-bearing C-glucosidic ellagitannins (castalagin, vescalagin and grandinin) with acyclovir (ACV) on the replication of type-1 and type-2 herpes simplex viruses in MDBK cells were tested by the focus-forming units reduction test. Ellagitannins included in these combinations possess a high individual antiviral activity: selectivity index of castalagin and vescalagin versus HSV-1 was similar to that of ACV, and relatively lower against HSV-2. The three-dimensional analytical approach of Prichard and Shipman was used to evaluate the impact of drug-drug interactions. The combination effects of ellagitannins with acyclovir were markedly synergistic.
三种含九羟氢酪醇的 C-葡萄糖基鞣花单宁（缩合鞣花酸、安石榴甙和诃黎勒酸）与阿昔洛韦（ACV）联合作用对 MDBK 细胞中 1 型和 2 型单纯疱疹病毒复制的影响通过空斑减少试验进行了测试。这些组合中包含的鞣花单宁具有很高的个体抗病毒活性：缩合鞣花酸和安石榴甙对 HSV-1 的选择性指数与 ACV 相似，而对 HSV-2 的相对较低。Prichard 和 Shipman 的三维分析方法用于评估药物相互作用的影响。鞣花单宁与阿昔洛韦的联合作用具有明显的协同作用。
