Rockman G E, Hall A, Markert L, Glavin G B
Department of Psychology, University of Winnipeg, Canada.
Physiol Behav. 1987;40(5):673-6. doi: 10.1016/0031-9384(87)90116-8.
The present study examined the effect of early maternal deprivation (early weaning) on voluntary ethanol consumption and responses to cold-immobilization stress in adult rats. Rats were weaned at 16 and 21 days of age and housed individually with food and water ad lib until they reached 190 +/- 5 g at which time half of the animals from each group were exposed to increasing concentrations (3 to 9%) of ethanol in a free choice with water every alternate day. Following acquisition of ethanol drinking, animals were provided with water and ethanol (9%) daily for eight days. At the end of this period, animals were divided into stressed and non-stressed groups. Stressed animals were exposed to cold immobilization stress for 3 hr. Results showed that the early-weaned animals consumed significantly more ethanol as compared to normal-weaned animals. Stomach pathology data revealed little ulcer formation in water-only groups. However, normal-weaned/ethanol-exposed animals exhibited significantly more severe ulcers when compared to all other water- or ethanol-exposed groups. We suggest that early maternal deprivation may predispose animals to increased ethanol consumption as adults. Stress ulcer susceptibility in these animals was likely influenced by interactions among the effects of early weaning, ethanol intake and handling and needs further clarification.
本研究考察了早期母体剥夺（早期断奶）对成年大鼠自愿摄入乙醇以及对冷束缚应激反应的影响。大鼠在16日龄和21日龄时断奶，并单独饲养，自由获取食物和水，直至体重达到190±5克，此时每组动物中的一半每隔一天在水的自由选择中接触浓度递增（3%至9%）的乙醇。在习得乙醇饮用后，每天给动物提供水和乙醇（9%），持续八天。在此阶段结束时，将动物分为应激组和非应激组。应激组动物接受3小时的冷束缚应激。结果表明，与正常断奶的动物相比，早期断奶的动物摄入的乙醇显著更多。胃部病理学数据显示，仅饮水组几乎没有溃疡形成。然而，与所有其他饮水或摄入乙醇组相比，正常断奶/接触乙醇的动物表现出明显更严重的溃疡。我们认为，早期母体剥夺可能使动物成年后更容易增加乙醇摄入量。这些动物的应激性溃疡易感性可能受到早期断奶、乙醇摄入以及处理等多种因素相互作用的影响，需要进一步阐明。
