Rockman G E, Hall A, Hong J, Glavin G B
Life Sci. 1987 Mar 30;40(13):1245-51. doi: 10.1016/0024-3205(87)90580-7.
The effects of exposure to a schedule of unpredictable cold-immobilization stress on voluntary ethanol consumption were examined. Following testing for ethanol preference, rats were divided into high, medium and low ethanol consuming groups on the basis of daily ethanol intake (g/kg/day) and exposed to immobilization stress over an 18 day period. Voluntary ethanol consumption was monitored during the stress period and for an additional 36 days post-stress. Results indicated a differential effect of stress on ethanol intake in that low ethanol consuming rats increased their ethanol intake during the stress period and maintained this increase throughout the entire post-stress period as compared to non-stressed controls. High ethanol consuming groups demonstrated a small (marginally significant) decrease in ethanol intake during the stress period as compared to baseline levels. No change in ethanol intake was observed for the medium ethanol consuming groups. The results suggest that unpredictable immobilization stress has a differential effect on ethanol intake depending upon pre-stress levels of ethanol consumption.
研究了暴露于不可预测的冷固定应激方案对自愿乙醇摄入量的影响。在进行乙醇偏好测试后，根据每日乙醇摄入量（克/千克/天）将大鼠分为高、中、低乙醇消费组，并在18天内暴露于固定应激。在应激期及应激后额外36天监测自愿乙醇摄入量。结果表明，应激对乙醇摄入量有不同影响，即与非应激对照组相比，低乙醇消费大鼠在应激期乙醇摄入量增加，并在整个应激后时期保持这种增加。高乙醇消费组在应激期乙醇摄入量与基线水平相比有小幅（边缘显著）下降。中等乙醇消费组未观察到乙醇摄入量变化。结果表明，不可预测的固定应激对乙醇摄入量的影响因应激前乙醇消费水平而异。
