Kelche C, Dalrymple-Alford J, Will B
Laboratoire de Neurobiologie des Comportements, Université Louis Pasteur, Strasbourg, France.
Physiol Behav. 1987;40(6):731-6. doi: 10.1016/0031-9384(87)90275-7.
We have previously found that rats given dorsal hippocampus lesions show reduced deficits on maze learning, spontaneous alternation and extinction tasks when housed postoperatively in an "enriched" as opposed to an "impoverished" environment. In contrast, postoperative enriched conditions were ineffective in rats given bilateral entorhinal cortex lesions. In this study, we examined whether postoperative differential housing would reduce the impairment in radial maze performance induced by fimbria-fornix transections. Significant interactions were found between lesion state and housing condition for the total number of errors made, the number of errors on the first eight arms visited and for the number of arms visited before the first error in an 8-arm maze. The interaction was due to the fact that, in sham-operated rats, isolated ones made more errors than enriched counterparts whereas, in rats with lesions, enriched ones showed no improvement of performance in comparison to isolated counterparts. These data suggest that the integrity of fimbria-fornix pathways is an important factor for the expression of facilitated maze performance in intact enriched rats and in enriched rats with hippocampal system damage.
我们之前发现，与饲养在“贫瘠”环境中相比，术后饲养在“丰富”环境中的大鼠，若其背侧海马体受损，在迷宫学习、自发交替和消退任务中的缺陷会减少。相比之下，术后处于丰富环境对双侧内嗅皮质受损的大鼠无效。在本研究中，我们检测了术后不同的饲养条件是否会减轻穹窿海马伞横断所致的放射状迷宫表现损伤。在错误总数、首次访问的前八条臂上的错误数量以及八臂迷宫中首次犯错之前访问的臂数方面，发现损伤状态与饲养条件之间存在显著的交互作用。这种交互作用是由于以下事实：在假手术大鼠中，单独饲养的大鼠比处于丰富环境中的大鼠犯错更多；而在受损大鼠中，与单独饲养的大鼠相比，处于丰富环境中的大鼠表现并未得到改善。这些数据表明，穹窿海马伞通路的完整性对于完整的丰富环境饲养大鼠以及海马系统受损的丰富环境饲养大鼠中迷宫表现的促进表达而言，是一个重要因素。
