Department of Psychological Sciences, The University of Connecticut, Storrs, Connecticut, USA.
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.
Eur Eat Disord Rev. 2023 May;31(3):425-432. doi: 10.1002/erv.2968. Epub 2023 Jan 30.
Family-based treatment (FBT) is a well-established intervention for adolescent anorexia nervosa (AN). Although FBT is efficacious in promoting weight gain and improvements in psychological symptoms, for some adolescents, cognitive/attitudinal recovery lags behind weight gain. This study conducted an exploratory post hoc analysis of outcomes of adolescents who achieved weight gain by the end of FBT but continued to experience elevated psychological symptoms post-treatment.
Data were drawn from two randomised controlled trials (RCTs) testing two forms of FBT (conjoint/whole family and parent-focussed). Descriptive statistics and generalised estimating equations were used to examine differences in treatment outcomes between non-cognitive responders (NCRs) (those who regained weight but continued to experience psychological symptoms) and full responders (FRs) (those who achieved both weight and cognitive restoration by the end of treatment) (n = 80; 83.7% female, Age [SD] = 14.66 [1.73]).
By 12 months post-treatment, there were no differences in weight between NCRs and FRs. However, NCRs had a slower trajectory of weight gain than FRs and continued to have elevated levels of psychological symptoms throughout the follow-up period.
A subset of adolescents appear to continue to experience clinically significant levels of eating pathology up to 12 months after FBT even when weight restoration is achieved.
家庭为基础的治疗(FBT)是一种成熟的青少年厌食症(AN)干预方法。尽管 FBT 在促进体重增加和改善心理症状方面是有效的,但对于一些青少年来说,认知/态度的恢复落后于体重增加。本研究对 FBT 结束时体重增加但治疗后仍持续出现心理症状升高的青少年进行了探索性事后分析。
数据来自两项随机对照试验(RCT),测试了两种形式的 FBT(联合/全家庭和父母为重点)。描述性统计和广义估计方程用于比较非认知反应者(NCRs)(体重恢复但仍持续出现心理症状)和完全反应者(FRs)(治疗结束时体重和认知恢复均达到)之间的治疗结果差异(n=80;83.7%为女性,年龄[SD]=14.66[1.73])。
治疗后 12 个月,NCRs 和 FRs 之间的体重无差异。然而,NCRs 的体重增加轨迹比 FRs 慢,并且在整个随访期间持续存在较高水平的心理症状。
即使体重恢复,在 FBT 后长达 12 个月,仍有一部分青少年持续经历临床显著水平的进食障碍。