Division of Cardiothoracic and Vascular Surgery, Surgical Director Heart Transplant, Mechanical Circulatory Support and ECMO, Lutheran Hospital, Indiana University School of Medicine - Fort Wayne (IUSM-FW), Fort Wayne, IN, USA.
Advanced Heart Failure, Transplant and MCS, Cleveland Clinic Heart Vascular and Thoracic Institute, Weston, FL, USA.
Perfusion. 2024 Apr;39(3):631-634. doi: 10.1177/02676591231154120. Epub 2023 Jan 30.
The potential for increased rates of morbidity of SARS-CoV-2 within immunocompromised populations has been of concern since the pandemic's onset. Transplant providers and patients can face particularly challenging situations, in the current settings as data continues to emerge for the prevention and treatment of the immunocompromised subpopulation. This case report details a patient 9-months post orthotopic heart transplant that developed SARS-CoV-2 infection despite two prior doses of the Pfizer-BioNtech COVID-19 vaccine, and had successful rescue from refractory hypoxemia with veno-venous extracorporeal membrane oxygenation (VV ECLS).
自疫情爆发以来，人们一直担心免疫功能低下人群中 SARS-CoV-2 发病率增加的可能性。在当前的数据不断涌现，用于预防和治疗免疫功能低下亚群的情况下，移植提供者和患者可能会面临特别具有挑战性的情况。本病例报告详细介绍了 1 例在接受原位心脏移植后 9 个月的患者，尽管已接种了 2 剂辉瑞-生物技术公司的 COVID-19 疫苗，但仍感染了 SARS-CoV-2，并且通过静脉-静脉体外膜氧合（VV ECMO）成功抢救了难治性低氧血症。
