Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.
National Congenital Anomaly and Rare Disease Registration Service, National Disease Registration Service, NHS Digital, Leeds, UK.
Rheumatology (Oxford). 2023 Sep 1;62(9):3117-3125. doi: 10.1093/rheumatology/kead051.
To describe the incidence of Kawasaki Disease (kDa) between 2006 and 2021 in England.
We identified all cases in hospital episode statistics with an ICD-10 diagnostic code M303 (for kDa) between 1 April 2006 and 31 March 2021. We validated 83 diagnoses using hospital medical records and found >97% accuracy. We calculated incidence rate ratios (IRRs) using Poisson regression and assessed the influence of age, sex, ethnicity and index of multiple deprivation (IMD). We used Office for National Statistics population estimates for England as the denominator.
We identified a total of 5908 cases of kDa in all children under the age of 16 (mean age 3.8, s.d.=3.2, 95% CI: 3.7, 3.9). Incidence in children aged <5 years was 8.9 (95% CI: 8.6, 9.2)/100 000 person-years; in children aged 5-9, 2.4 (95% CI: 2.3, 2.6)/100 000 person-years; and in children aged 10-15, 0.6 (95% CI: 0.6, 0.7). Male : female ratio was 1.5 : 1. Incidence was higher among non-White than White ethnicities [adjusted IRR 2.1 (2.0-2.2) for Asian, 3.0 (2.8-3.3) for Black and 4.5 (4.2-4.8) for other ethnicities]. The incidence increased with socioeconomic deprivation; the adjusted IRR of the least deprived IMD quintile compared with the most deprived quintile was 0.81 (0.77-0.84).
Incidence rates of kDa derived from hospital admission data in England were higher than in studies relying on clinician reporting. We confirm previous findings on the influence of sex and ethnicity on kDa incidence and observe that there was a higher incidence of kDa within more deprived socioeconomic groups.
描述 2006 年至 2021 年期间英国川崎病（kDa）的发病率。
我们在 2006 年 4 月 1 日至 2021 年 3 月 31 日期间，在医院病例统计数据中使用 ICD-10 诊断代码 M303（用于 kDa）确定了所有病例。我们使用医院病历验证了 83 例诊断，准确率超过 97%。我们使用泊松回归计算发病率比值（IRR），并评估了年龄、性别、种族和多重剥夺指数（IMD）的影响。我们使用英国国家统计局的人口估计数作为分母。
我们在所有 16 岁以下儿童中总共确定了 5908 例 kDa（平均年龄 3.8 岁，标准差=3.2，95%置信区间：3.7，3.9）。5 岁以下儿童的发病率为 8.9（95%置信区间：8.6，9.2）/100000 人年；5-9 岁儿童为 2.4（95%置信区间：2.3，2.6）/100000 人年；10-15 岁儿童为 0.6（95%置信区间：0.6，0.7）。男：女比例为 1.5：1。非白种人比白种人发病率更高[亚洲人调整后的发病率比值比（IRR）为 2.1（2.0-2.2），黑人 3.0（2.8-3.3），其他种族 4.5（4.2-4.8）]。发病率随社会经济剥夺程度而增加；与最贫困 IMD 五分位数相比，最不贫困五分位数的调整后 IRR 为 0.81（0.77-0.84）。
从英国住院数据中得出的 kDa 发病率高于依赖临床医生报告的研究。我们确认了性别和种族对 kDa 发病率的影响的先前发现，并观察到在社会经济地位较低的群体中 kDa 的发病率更高。
