Department of Physical Chemistry of Polymers, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Chembiochem. 2023 Apr 3;24(7):e202200718. doi: 10.1002/cbic.202200718. Epub 2023 Mar 1.
Polymersome-based biomimetic nanoreactors (PBNs) have generated great interest in nanomedicine and cell mimicry due to their robustness, tuneable chemistry, and broad applicability in biologically relevant fields. In this concept review, we mainly discuss the state of the art in functional polymersomes as biomimetic nanoreactors with membrane-controlled transport. PBNs that use environmental changes or external stimuli to adjust membrane permeability while maintaining structural integrity are highlighted. By encapsulating catalytic species, PBNs are able to convert inactive substrates into functional products in a controlled manner. In addition, special attention is paid to the use of PBNs as tailored artificial organelles with biomedical applications in vitro and in vivo, facilitating the fabrication of next-generation artificial organelles as therapeutic nanocompartments.
基于聚合物囊泡的仿生纳米反应器 (PBNs) 由于其稳定性、可调谐的化学性质以及在生物学相关领域的广泛适用性，在纳米医学和细胞模拟领域引起了极大的兴趣。在本概念综述中，我们主要讨论了作为具有膜控输运的仿生纳米反应器的功能聚合物囊泡的最新进展。重点介绍了利用环境变化或外部刺激来调节膜通透性，同时保持结构完整性的 PBNs。通过包封催化物种，PBNs 能够以可控的方式将非活性底物转化为功能性产物。此外，特别关注了 PBNs 在作为具有生物医学应用的定制人工细胞器中的应用，这有助于制造下一代作为治疗性纳米隔室的人工细胞器。
