Karamyan Vardan T
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.
Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI, USA.
Methods Mol Biol. 2023;2616:369-377. doi: 10.1007/978-1-0716-2926-0_25.
Development of stroke recovery therapies is an active field of research and represents an opportunity to reduce the global impact of stroke as the leading cause of acquired, long-term disability in adults. The negative outcomes of recent large-scale clinical trials have highlighted deficiencies in the translational process and endanger the trajectory of post-stroke recovery research. Because of this, a number of strategies have been recommended by experts to better navigate the translational pipeline. To assist the field in advancing to the next stage for successful clinical translation, the goal of this chapter is to discuss concepts relevant to the experimental design of in vivo preclinical pharmacological studies to make them clinically relevant and informative for future trials.
中风康复疗法的开发是一个活跃的研究领域，也是一个减少中风全球影响的契机，因为中风是成年人后天长期残疾的主要原因。近期大规模临床试验的负面结果凸显了转化过程中的不足，并危及中风后康复研究的发展轨迹。因此，专家们推荐了一些策略，以更好地推进转化流程。为了帮助该领域进入成功临床转化的下一阶段，本章的目标是讨论与体内临床前药理学研究实验设计相关的概念，使其具有临床相关性，并为未来试验提供信息。
