Sabanci Nanotechnology Research and Application Center, Istanbul 34956, Turkey.
Sabanci University Faculty of Engineering and Natural Sciences, Istanbul 34956, Turkey.
Biofabrication. 2023 Feb 14;15(2). doi: 10.1088/1758-5090/acb73d.
Tissue interfaces include complex gradient structures formed by transitioning of biochemical and mechanical properties in micro-scale. This characteristic allows the communication and synchronistic functioning of two adjacent but distinct tissues. It is particularly challenging to restore the function of these complex structures by transplantation of scaffolds exclusively produced by conventional tissue engineering methods. Three-dimensional (3D) bioprinting technology has opened an unprecedented approach for precise and graded patterning of chemical, biological and mechanical cues in a single construct mimicking natural tissue interfaces. This paper reviews and highlights biochemical and biomechanical design for 3D bioprinting of various tissue interfaces, including cartilage-bone, muscle-tendon, tendon/ligament-bone, skin, and neuro-vascular/muscular interfaces. Future directions and translational challenges are also provided at the end of the paper.
组织界面包括在微尺度上通过生化和机械性能的转变形成的复杂梯度结构。这种特性允许两个相邻但不同的组织进行通信和同步功能。通过仅使用传统组织工程方法生产的支架进行移植，来恢复这些复杂结构的功能特别具有挑战性。三维（3D）生物打印技术为在单个构建体中模拟天然组织界面的化学、生物和机械线索的精确和分级图案化开辟了前所未有的方法。本文综述并强调了用于各种组织界面（包括软骨-骨、肌肉-肌腱、肌腱/韧带-骨、皮肤以及神经血管/肌肉界面）的 3D 生物打印的生物化学和生物力学设计。文末还提供了未来的方向和转化挑战。
