新型硬蜱防治策略的假定神经节靶标。
Putative target sites in synganglion for novel ixodid tick control strategies.
机构信息
Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Instituto de Pesquisas Veterinárias Desidério Finamor - Centro de Pesquisa em Saúde Animal, Secretaria da Agricultura, Pecuária e Desenvolvimento Rural, Eldorado do Sul, RS, Brazil; Instituto Nacional de Ciência e Tecnologia - Entomologia Molecular, Rio de Janeiro, RJ, Brazil.
出版信息
Ticks Tick Borne Dis. 2023 May;14(3):102123. doi: 10.1016/j.ttbdis.2023.102123. Epub 2023 Jan 19.
Acaricide resistance is a global problem that has impacts worldwide. Tick populations with broad resistance to all commercially available acaricides have been reported. Since resistance selection in ticks and their role in pathogen transmission to animals and humans result in important economic and public health burden, it is essential to develop new strategies for their control (i.e., novel chemical compounds, vaccines, biological control). The synganglion is the tick central nervous system and it is responsible for synthesizing and releasing signaling molecules with different physiological functions. Synganglion proteins are the targets of the majority of available acaricides. In this review we provide an overview of the mode-of-action and resistance mechanisms against neurotoxic acaricides in ticks, as well as putative target sites in synganglion, as a supporting tool to identify new target proteins and to develop new strategies for tick control.
杀蜱剂耐药性是一个全球性问题，对全球都有影响。已经有报道称，蜱虫对所有市售杀蜱剂都有广泛的耐药性。由于蜱虫的耐药性选择及其在将病原体传播给动物和人类方面的作用导致了重要的经济和公共卫生负担，因此开发新的控制策略（即新型化合物、疫苗、生物控制）至关重要。感器是蜱虫的中央神经系统，它负责合成和释放具有不同生理功能的信号分子。感器蛋白是大多数可用杀蜱剂的作用靶点。在这篇综述中，我们概述了蜱虫神经毒性杀蜱剂的作用模式和耐药机制，以及感器中可能的靶位，作为识别新靶蛋白和开发蜱虫控制新策略的辅助工具。
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