Aging and Neuroscience Laboratory, Federal University of Paraíba, João Pessoa, Brazil; Graduate Program in Cognitive and Behavioural Neuroscience, Federal University of Paraíba, João Pessoa, Brazil.
Graduate Program in Cognitive and Behavioural Neuroscience, Federal University of Paraíba, João Pessoa, Brazil.
Neurophysiol Clin. 2023 Feb;53(1):102839. doi: 10.1016/j.neucli.2022.102839. Epub 2023 Jan 28.
This study compared electroencephalography microstates (EEG-MS) of patients with Parkinson's disease (PD) to healthy controls and correlated EEG-MS with motor and non-motor aspects of PD.
This cross-sectional exploratory study was conducted with patients with PD (n = 10) and healthy controls (n = 10) matched by sex and age. We recorded EEG-MS using 32 channels during eyes-closed and eyes-open conditions and analyzed the four classic EEG-MS maps (A, B, C, D). Clinical information (e.g., disease duration, medications, levodopa equivalent daily dose), motor (Movement Disorder Society - Unified Parkinson Disease Rating Scale II and III, Timed Up and Go simple and dual-task, and Mini-Balance Evaluation Systems Test) and non-motor aspects (Mini-Mental State Exam [MMSE], verbal fluency, Hospital Anxiety and Depression Scale, and Parkinson's Disease Questionnaire-39 [PDQ-39]) were assessed in the PD group. Mann-Whitney U test was used to compare groups, and Spearman's correlation coefficient to analyze the correlations between coverage of EEG-MS and clinical aspects of PD.
The PD group showed a shorter duration of EEG-MS C in the eyes-closed condition than the control group. We observed correlations (rho = 0.64 to 0.82) between EEG-MS B, C, and D and non-motor aspects of PD (MMSE, verbal fluency, PDQ-39, and levodopa equivalent daily dose).
Alterations in EEG-MS and correlations between topographies and cognitive aspects, quality of life, and medication dose indicate that EEG could be used as a PD biomarker. Future studies should investigate these associations using a longitudinal design.
本研究比较了帕金森病（PD）患者与健康对照者的脑电微状态（EEG-MS），并将 EEG-MS 与 PD 的运动和非运动方面相关联。
这是一项横断面探索性研究，纳入了 10 例 PD 患者（n=10）和年龄、性别匹配的健康对照者（n=10）。我们在闭眼和睁眼状态下使用 32 通道记录 EEG-MS，并分析了四个经典的 EEG-MS 图谱（A、B、C、D）。在 PD 组中评估了临床信息（例如，疾病持续时间、药物、左旋多巴等效日剂量）、运动（运动障碍协会统一帕金森病评定量表 II 和 III、计时起立行走简单和双重任务、简易平衡评估系统测试）和非运动方面（简易精神状态检查[MMSE]、言语流畅性、医院焦虑抑郁量表和帕金森病问卷-39[PDQ-39]）。使用曼-惠特尼 U 检验比较组间差异，采用斯皮尔曼相关系数分析 EEG-MS 覆盖率与 PD 临床特征的相关性。
PD 组在闭眼状态下的 EEG-MS C 持续时间短于对照组。我们观察到 EEG-MS B、C 和 D 与非运动方面（MMSE、言语流畅性、PDQ-39 和左旋多巴等效日剂量）之间存在相关性（rho=0.64 至 0.82）。
EEG-MS 的改变以及地形图与认知方面、生活质量和药物剂量之间的相关性表明，EEG 可作为 PD 的生物标志物。未来的研究应使用纵向设计来进一步探讨这些关联。
