Newmark S R, Rossini A A, Naftolin F I, Todd R, Rose L I, Cahill G F
Am J Obstet Gynecol. 1979 Jan 1;133(1):75-80. doi: 10.1016/0002-9378(79)90415-0.
Five obese women were studied before and at the end of a prolonged fast to determine the effect on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and on the response to luteinizing hormone--releasing factor (LRF). Although baseline serum LH values declined from a mean value of 9.1 to 6.5 m.I.U. per milliliter measured at the end of the fast, these changes in mean serum level were not statistically significant. However, the integrated LH secretion did decline when measured at the end of the fasts (p less than 0.05). FSH secretion did not change. LRF-stimulated LH and FSH values showed augmented stimulation at the end of the fast. Pulsatile gonadotropin secretion patterns remained normal. Prolonged fasting appears to alter the baseline LH secretion and the pituitary response to exogenous LRF.
对五名肥胖女性在长期禁食前和禁食结束时进行了研究，以确定禁食对促黄体生成素（LH）和促卵泡生成素（FSH）以及对促黄体生成素释放因子（LRF）反应的影响。尽管空腹结束时测得的血清LH基线值从平均值每毫升9.1毫国际单位降至6.5毫国际单位，但血清平均水平的这些变化无统计学意义。然而，在禁食结束时测量时，LH的综合分泌确实下降了（p小于0.05）。FSH分泌没有变化。禁食结束时，LRF刺激的LH和FSH值显示刺激增强。促性腺激素的脉冲分泌模式保持正常。长期禁食似乎会改变LH的基线分泌以及垂体对外源性LRF的反应。
