Prokudina E A, Borovitskaia A E, Kadyrova N O, Rzhononitskaia L P
Radiobiologiia. 1987 Sep-Oct;27(5):653-6.
Purine derivatives, meradine and ethimizole, are shown to exert a therapeutic effect with respect to survival of rats exposed to 4 Gy radiation. Distinctions in the death rate between the exposed rats and rats treated with meradine and ethimizole are manifested 1 month following irradiation, i. e. at the time of clinical recovery of the exposed body. The preparations used at other te terms are uneffective. It is suggested that purine derivatives increase the regeneration and compensation of radiation lesions at the time of clinical recovery reducing an irreversible component of radiation damage.
嘌呤衍生物美拉定和乙咪唑对受4 Gy辐射的大鼠具有治疗作用，可提高其存活率。受辐射大鼠与用美拉定和乙咪唑治疗的大鼠之间的死亡率差异在辐照后1个月出现，即受辐射机体临床恢复时。在其他时期使用这些制剂无效。有人认为，嘌呤衍生物在临床恢复时可促进辐射损伤的再生和代偿，减少辐射损伤的不可逆成分。
