Ji Lin, Deng Huan, Xue Huimin, Wang Jiting, Hong Kexin, Gao Yunxiao, Kang Xiping, Fan Guanghe, Huang Weidong, Zhan Jicheng, You Yilin
College of Food Science and Nutritional Engineering, Beijing Key Laboratory of Viticulture and Enology, China Agricultural University, Beijing, China.
Compr Rev Food Sci Food Saf. 2023 Mar;22(2):1128-1147. doi: 10.1111/1541-4337.13106. Epub 2023 Jan 30.
Phenolic acids (PAs), a class of small bioactive molecules widely distributed in food and mainly found as secondary plant metabolites, present significant advantages such as antioxidant activity and other health benefits. The global epidemic of nonalcoholic fatty liver disease (NAFLD) is becoming a serious public health problem. Existing studies showed that gut microbiota (GM) dysbiosis is highly associated with the occurrence and development of NAFLD. In recent years, progress has been made in the study of the relationship among PA compounds, GM, and NAFLD. PAs can regulate the composition and functions of the GM to promote human health, while GM can increase the dietary sources of PAs and improve its bioavailability. This paper discussed PAs, GM, and their interrelationship while introducing several representative dietary PA sources and examining the absorption and metabolism of PAs mediated by GM. It also summarizes the effect and mechanisms of PAs in improving and regulating NAFLD via GM and their metabolites. This helps to better evaluate the potential preventive effect of PAs on NAFLD via the regulation of GM and expands the utilization of PAs and PA-rich food resources.
酚酸（PAs）是一类广泛分布于食物中的小分子生物活性分子，主要作为植物次生代谢产物存在，具有抗氧化活性等显著优势以及其他对健康有益的功效。非酒精性脂肪性肝病（NAFLD）的全球流行正成为一个严重的公共卫生问题。现有研究表明，肠道微生物群（GM）失调与NAFLD的发生和发展高度相关。近年来，在PA化合物、GM和NAFLD之间关系的研究方面取得了进展。PAs可以调节GM的组成和功能以促进人类健康，而GM可以增加PAs的膳食来源并提高其生物利用度。本文在介绍几种具有代表性的膳食PA来源并研究GM介导的PAs吸收和代谢的同时，讨论了PAs、GM及其相互关系。它还总结了PAs通过GM及其代谢产物改善和调节NAFLD的作用及机制。这有助于更好地评估PAs通过调节GM对NAFLD的潜在预防作用，并扩大PAs和富含PA的食物资源的利用。
