免疫系统中的水通道蛋白。
Aquaporins in Immune System.
作者信息
Quan Yazhu, Kan Bo, Yang Baoxue
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China.
Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University, Beijing, China.
出版信息
Adv Exp Med Biol. 2023;1398:195-202. doi: 10.1007/978-981-19-7415-1_13.
Recent studies have shown that at least six aquaporins (AQPs), including AQP1, AQP3, AQP4, AQP5, AQP7, and AQP9, are expressed in immune system. These AQPs distribute in lymphocytes, macrophages, dendritic cells, and neutrophils, and mediate water and glycerol transportation in these cells, which play important roles in innate and adaptive immune functions. Immune system plays important roles in body physiological functions and health. Therefore, understanding the association between AQPs and immune system may provide approaches to prevent and treat related diseases. Here we will discuss the expression and physiological functions of AQPs in immune system and summarize recent researches on AQPs in immune diseases.
最近的研究表明，包括水通道蛋白1（AQP1）、水通道蛋白3（AQP3）、水通道蛋白4（AQP4）、水通道蛋白5（AQP5）、水通道蛋白7（AQP7）和水通道蛋白9（AQP9）在内的至少六种水通道蛋白在免疫系统中表达。这些水通道蛋白分布于淋巴细胞、巨噬细胞、树突状细胞和中性粒细胞中，并介导这些细胞中的水和甘油运输，这在固有免疫和适应性免疫功能中发挥着重要作用。免疫系统在机体生理功能和健康中发挥着重要作用。因此，了解水通道蛋白与免疫系统之间的关联可能为预防和治疗相关疾病提供途径。在此，我们将讨论水通道蛋白在免疫系统中的表达和生理功能，并总结近期关于免疫疾病中水通道蛋白的研究。
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