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补骨脂酚: 来自 Linn. 的一种潜在的抗癌化合物

Bakuchiol: A Potential Anticancer Compound from Linn.

机构信息

Department of Pharmacy, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, 135001, Haryana, India.

Department of Pharmacy, MM College of Pharmacy, Maharishi Markandeshwer (Deemed to be University), Mullana, Ambala, India.

出版信息

Anticancer Agents Med Chem. 2023;23(9):989-998. doi: 10.2174/1871520623666230130102910.

DOI:10.2174/1871520623666230130102910
PMID:36717993
Abstract

BACKGROUND

Bakuchiol is a monoterpene phenol isolated from the seeds of Psoralea corylifolia Linn. It is used traditionally in Indian and Chinese medicine and has been reported to possess extensive pharmacological potential against a variety of ailments. A recent study enumerates the anticancer potential of bakuchiol.

OBJECTIVE

The objective of the present review study is to explore the anticancer potential of bakuchiol which provides insight into the design and develop novel molecular entities against various disorders.

METHODS

Current prose and patents emphasizing the anticancer potential of bakuchiol have been identified and reviewed with particular emphasis on their scientific impact and novelty. An extensive literature survey was performed and compiled via the search engine, PubMed, Science Direct, and from many reputed foundations.

RESULTS

The study's findings suggested and verified the anticancer potential that Psoralea and bakuchiol against a variety of cancer. Both Psoralea and bakuchiol also portrayed synergistic or potentiating effects when given in combination with other anticancer drugs or natural compounds.

CONCLUSION

Altogether, the promising anticancer potential of bakuchiol may open new probes for therapeutic invention in various types of tumors. Thus, the present review gives the erudition of bakuchiol and Psoralea as anticancer which paves the way for further work in exploring their potential.

摘要

背景

补骨脂酚是从补骨脂种子中分离得到的单萜酚类化合物。它在印度和中国传统医学中被广泛使用,并被报道具有广泛的药理学潜力,可以治疗多种疾病。最近的一项研究列举了补骨脂酚的抗癌潜力。

目的

本综述研究的目的是探讨补骨脂酚的抗癌潜力,为设计和开发针对各种疾病的新型分子实体提供了思路。

方法

确定并综述了目前强调补骨脂酚抗癌潜力的散文和专利,特别强调了它们的科学影响和新颖性。通过搜索引擎 PubMed、Science Direct 和许多著名基金会进行了广泛的文献调查和编译。

结果

研究结果表明并验证了补骨脂和补骨脂酚对多种癌症的抗癌潜力。补骨脂和补骨脂酚联合使用其他抗癌药物或天然化合物时,也表现出协同或增效作用。

结论

总的来说,补骨脂酚具有很大的抗癌潜力,可能为各种类型的肿瘤的治疗发明开辟新的途径。因此,本综述提供了补骨脂酚和补骨脂作为抗癌药物的知识,为进一步探索其潜力铺平了道路。

相似文献

1
Bakuchiol: A Potential Anticancer Compound from Linn.补骨脂酚: 来自 Linn. 的一种潜在的抗癌化合物
Anticancer Agents Med Chem. 2023;23(9):989-998. doi: 10.2174/1871520623666230130102910.
2
Therapeutic and Health Promoting Potential of Bakuchiol from : A Comprehensive Review.没食子酸辛醇的治疗和健康促进潜力:全面综述。
Endocr Metab Immune Disord Drug Targets. 2023;23(9):1125-1136. doi: 10.2174/1871530323666230207123613.
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Seed Extract of and Its Constituent Bakuchiol Impairs AHL-Based Quorum Sensing and Biofilm Formation in Food- and Human-Related Pathogens.和其成分补骨脂素的种子提取物可破坏基于 AHL 的群体感应并抑制食源性病原体和人源相关病原体的生物膜形成。
Front Cell Infect Microbiol. 2018 Oct 25;8:351. doi: 10.3389/fcimb.2018.00351. eCollection 2018.
4
Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage.补骨脂种子中分离得到的化合物对氧化应激诱导的视网膜损伤的保护作用。
Toxicol Appl Pharmacol. 2013 Jun 1;269(2):109-20. doi: 10.1016/j.taap.2013.03.017. Epub 2013 Mar 29.
5
Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia.补骨脂及其对HT22海马细胞和BV-2小胶质细胞的神经保护和抗神经炎症作用的定量分析
Molecules. 2016 Aug 17;21(8):1076. doi: 10.3390/molecules21081076.
6
Bakuchiol, a natural constituent and its pharmacological benefits.补骨脂酚,一种天然成分及其药理学益处。
F1000Res. 2023 Nov 7;12:29. doi: 10.12688/f1000research.129072.2. eCollection 2023.
7
Characteristics of bakuchiol - the compound with high biological activity and the main source of its acquisition - (L.) Medik.补骨脂素的特性 - 具有高生物活性的化合物及其主要获取来源 - (L.)Medik.
Nat Prod Res. 2021 Dec;35(24):5828-5842. doi: 10.1080/14786419.2020.1837813. Epub 2020 Nov 13.
8
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo.补骨脂中(S)-补骨脂酚对大鼠肝损伤的体内外保护作用
Planta Med. 2005 Jun;71(6):508-13. doi: 10.1055/s-2005-864150.
9
HPLC Method for Simultaneous Quantification of Bakuchiol and Minor Furocoumarins in Bakuchiol Extract from Psoralea corylifolia.高效液相色谱法同时测定补骨脂中补骨脂酚提取物中补骨脂酚和微量呋喃香豆素的含量
J AOAC Int. 2015 Jul-Aug;98(4):902-6. doi: 10.5740/jaoacint.14-228.
10
Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague-Dawley rats.补骨脂乙醇提取物及其主要成分补骨脂酚可减少去卵巢Sprague-Dawley大鼠的骨质流失。
Br J Nutr. 2009 Apr;101(7):1031-9. doi: 10.1017/S0007114508066750. Epub 2008 Sep 19.

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