Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.
Cancer Rep (Hoboken). 2024 Oct;7(10):e70012. doi: 10.1002/cnr2.70012.
Breast cancer is a common form of cancer among women characterized by the growth of malignant cells in the breast tissue. The most common treatments for this condition include chemotherapy, surgical intervention, radiation therapy, hormone therapy, and biological therapy. The primary issues associated with chemotherapy and radiation therapy are their adverse events and significant financial burden among patients in underdeveloped countries. This highlights the need to explore and develop superior therapeutic options that are less detrimental and more economically efficient. Plants provide an abundant supply of innovative compounds and present a promising new avenue for investigating cancer. Plants and their derivations are undergoing a revolution due to their reduced toxicity, expediency, cost-effectiveness, safety, and simplicity in comparison to conventional treatment methods. Natural products are considered promising candidates for the development of anticancer drugs, due perhaps to the diverse pleiotropic effects on target events. The effects of plant-derived products are limited to cancer cells while leaving healthy cells unaffected. Identification of compounds with strong anticancer properties and development of plant-based medications for cancer treatment might be crucial steps in breast cancer therapy. Although bioactive compounds have potent anticancer properties, they also have drawbacks that need to be resolved before their application in clinical trials and improved for the approved drugs. This study aims to give comprehensive information on known anticancer compounds, including their sources and molecular mechanisms of actions, along with opportunities and challenges in plant-based anticancer therapies.
乳腺癌是女性中常见的癌症类型，其特征是乳腺组织中恶性细胞的生长。这种疾病的最常见治疗方法包括化疗、手术干预、放射治疗、激素治疗和生物治疗。与化疗和放射治疗相关的主要问题是它们的不良反应以及在欠发达国家患者中的巨大经济负担。这突出表明需要探索和开发更优越的治疗选择，这些选择的副作用更小，且更经济高效。植物为创新化合物提供了丰富的供应，为癌症研究提供了一个有前途的新途径。由于与传统治疗方法相比，植物及其衍生物的毒性降低、方便、具有成本效益、安全且简单，因此它们正在经历一场革命。天然产物被认为是开发抗癌药物的有希望的候选物，这可能是因为它们对靶事件具有多种多效性的影响。植物衍生产品的作用仅限于癌细胞，而不会影响健康细胞。鉴定具有强抗癌特性的化合物并开发基于植物的癌症治疗药物可能是乳腺癌治疗的关键步骤。尽管生物活性化合物具有强大的抗癌特性，但它们也存在需要在临床试验中应用之前解决的缺点，并需要对已批准的药物进行改进。本研究旨在提供有关已知抗癌化合物的综合信息，包括它们的来源和作用机制，以及植物抗癌疗法中的机遇和挑战。
