Maleki Mohsen, Karajibani Mansour, Sarvani Mohsen, Montazerifar Farzaneh, Salimi Saeedeh, Heidari Zahra
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Health Promotion Research Center, Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Mol Biol Res Commun. 2022;11(3):113-118. doi: 10.22099/mbrc.2022.43012.1714.
About 60-80% of thyroid cancer (TC) cases are papillary thyroid cancer (PTC). Studies have shown that serum adiponectin levels are inversely related to the risk of TC and PTC. Aim of the present study was to evaluate the association between adiponectin rs2241766 and rs266729 polymorphisms and risk of PTC. 122 PTC patients and 128 healthy subjects were enrolled in the study. PCR-RFLP and ARMS-PCR methods were used for genotype analysis. The rs266729 polymorphism did not correlate with risk of PTC. As regard rs2241766 polymorphism, the frequency of the GG genotype did not have a significant difference between the two groups, although, PTC cases showed higher frequency of GT genotype compared to controls (OR=2.87, 95% CI=1.56-5.28, P=0.001). We observed a significant association between adiponectin rs2241766 polymorphism and PTC, however, our result showed no significant relationship between adiponectin rs266729 polymorphism and risk of PTC.
约60 - 80%的甲状腺癌（TC）病例为乳头状甲状腺癌（PTC）。研究表明，血清脂联素水平与TC和PTC的风险呈负相关。本研究的目的是评估脂联素rs2241766和rs266729多态性与PTC风险之间的关联。122例PTC患者和128名健康受试者纳入本研究。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）和扩增阻滞突变系统-聚合酶链反应（ARMS-PCR）方法进行基因分型分析。rs266729多态性与PTC风险无关。关于rs2241766多态性，两组间GG基因型频率无显著差异，尽管PTC病例中GT基因型频率高于对照组（比值比[OR]=2.87，95%可信区间[CI]=1.56 - 5.28，P=0.001）。我们观察到脂联素rs2241766多态性与PTC之间存在显著关联，然而，我们的结果显示脂联素rs266729多态性与PTC风险之间无显著关系。
