Damoiseaux Jan, van Beers Joyce
Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands.
J Transl Autoimmun. 2023 Jan 21;6:100191. doi: 10.1016/j.jtauto.2023.100191. eCollection 2023.
Autoantibodies, in particular anti-dsDNA antibodies, are increasingly used for diagnosis, classification and follow-up of patients with SLE. Since standardization of autoantibody assays is a major challenge, more attention should be paid to harmonization initiatives and better definition of required test characteristics in classification criteria. For diagnosis and follow-up separate multi-center studies are required to establish test characteristics of distinct immuno-assays for both purposes. Finally, such studies should consider not to evaluate SLE as a single disease, but as a disease with distinct subtypes.
自身抗体，尤其是抗双链DNA抗体，越来越多地用于系统性红斑狼疮（SLE）患者的诊断、分类和随访。由于自身抗体检测的标准化是一项重大挑战，因此应更加关注协调举措，并在分类标准中更好地定义所需的检测特征。为了进行诊断和随访，需要开展单独的多中心研究，以确定用于这两个目的的不同免疫检测的检测特征。最后，此类研究应考虑不要将SLE视为单一疾病，而是视为具有不同亚型的疾病。
