Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.
School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia.
Cells. 2023 Sep 30;12(19):2387. doi: 10.3390/cells12192387.
Vitamin D is one significant prohormone substance in human organ systems. It is a steroidal hormone produced in the skin upon exposure to UVB rays. This paper presents a systematic review of the utilization of topical vitamin D, specifically cholecalciferol, calcipotriol, and tacalcitol, in the treatment of vitiligo. It considers the role of vitamin D in stimulating the synthesis of melanin and melanogenesis, which can help with the process of repigmentation. The inclusion of calcipotriol or tacalcitol in Narrowband Ultraviolet Phototherapy (NB-UVB) has shown the potential to enhance therapeutic outcomes for vitiligo. However, their effectiveness in combination with Psoralens Long Wave Ultraviolet Radiation (PUVA) and Monochromatic Excimer Light (MEL) treatment for vitiligo is limited. In contrast, combining topical corticosteroids with vitamin D analogues has demonstrated superior efficacy in treating vitiligo compared to using vitamin D analogues alone, while also providing the added benefit of reducing corticosteroid-related adverse effects. In addition, treating stable vitiligo with topical cholecalciferol and microneedling has shown success. Future studies are needed to ascertain an efficient method of administering vitamin D topically as an anti-vitiligo agent.
维生素 D 是人体器官系统中一种重要的前激素物质。它是一种类固醇激素，在皮肤暴露于 UVB 射线时产生。本文系统回顾了局部使用维生素 D，特别是胆钙化醇、卡泊三醇和他卡西醇，治疗白癜风的情况。它考虑了维生素 D 在刺激黑色素合成和黑色素生成中的作用，这有助于色素沉着过程。将卡泊三醇或他卡西醇纳入窄带紫外线光疗（NB-UVB）中已显示出增强白癜风治疗效果的潜力。然而，它们与补骨脂素长波紫外线辐射（PUVA）和单色准分子光（MEL）联合治疗白癜风的效果有限。相比之下，与单独使用维生素 D 类似物相比，将局部皮质类固醇与维生素 D 类似物联合使用在治疗白癜风方面具有更好的疗效，同时还减少了皮质类固醇相关的不良反应。此外，局部使用胆钙化醇和微针治疗稳定的白癜风已取得成功。需要进一步的研究来确定将维生素 D 作为一种抗白癜风药物进行局部给药的有效方法。
