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妊娠期甲状腺癌:诊断、管理与治疗。

Thyroid cancer in pregnancy: diagnosis, management, and treatment.

机构信息

Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.

Department of Radiology and Imaging Science, University of Rochester, Rochester, NY, USA.

出版信息

Abdom Radiol (NY). 2023 May;48(5):1724-1739. doi: 10.1007/s00261-023-03808-1. Epub 2023 Jan 31.

DOI:10.1007/s00261-023-03808-1
PMID:36719426
Abstract

The evaluation and management of cancer during pregnancy requires special care to assure the health and safety of both the mother and fetus. The diagnosis and treatment of thyroid cancer in the non-pregnant patient often involves radioactive iodine exposure. However, radioactive iodine is contraindicated in pregnancy and surgical interventions pose risks to both the mother and fetus. Thus, the management of thyroid cancer during pregnancy is a unique clinical challenge. In this review, we discuss the imaging of thyroid nodules during pregnancy, including the role of CT, MRI, and nuclear Imaging, as well as that of Ultrasound and FNA. The staging and prognosis are discussed along with the management, treatment, and surveillance of thyroid cancer in pregnancy. Finally, the risks to the fetus through treatment are examined. Case examples are provided with an emphasis on the appropriate direction of care from a radiologist's perspective.

摘要

怀孕期间癌症的评估和管理需要特别注意,以确保母亲和胎儿的健康和安全。非孕妇甲状腺癌的诊断和治疗通常涉及放射性碘暴露。然而,放射性碘在怀孕期间是禁忌的,手术干预对母亲和胎儿都有风险。因此,怀孕期间甲状腺癌的管理是一个独特的临床挑战。在这篇综述中,我们讨论了怀孕期间甲状腺结节的影像学检查,包括 CT、MRI 和核成像的作用,以及超声和细针抽吸活检的作用。我们还讨论了分期和预后,以及怀孕期间甲状腺癌的管理、治疗和监测。最后,我们研究了治疗对胎儿的风险。提供了病例示例,并强调了从放射科医生的角度来看,适当的护理方向。

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Overview of the 2022 WHO Classification of Thyroid Neoplasms.2022 年世卫组织甲状腺肿瘤分类概述。
Endocr Pathol. 2022 Mar;33(1):27-63. doi: 10.1007/s12022-022-09707-3. Epub 2022 Mar 14.
2
Surgical Considerations in Thyroid Cancer: What the Radiologist Needs to Know.甲状腺癌的外科治疗注意事项:放射科医生需要了解的内容。
Neuroimaging Clin N Am. 2021 Aug;31(3):327-335. doi: 10.1016/j.nic.2021.04.010.
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Thyroid cancer incidence trends by histology in 25 countries: a population-based study.25 个国家基于人群的甲状腺癌发病率的组织学趋势研究。
Lancet Diabetes Endocrinol. 2021 Apr;9(4):225-234. doi: 10.1016/S2213-8587(21)00027-9. Epub 2021 Mar 1.
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Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015.美国青少年和青年人群癌症发病率趋势,1973-2015 年。
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Evaluation of Overall Survival in Patients With Anaplastic Thyroid Carcinoma, 2000-2019.2000-2019 年间间变性甲状腺癌患者总生存评估。
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ACR Appropriateness Criteria Thyroid Disease.美国放射学会适宜性标准:甲状腺疾病
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Thyroid Function Reference Values in Healthy Iodine-Sufficient Pregnant Women and Influence of Thyroid Nodules on Thyrotropin and Free Thyroxine Values.健康碘充足孕妇的甲状腺功能参考值及甲状腺结节对促甲状腺激素和游离甲状腺素值的影响。
Thyroid. 2019 Mar;29(3):421-429. doi: 10.1089/thy.2018.0324. Epub 2019 Feb 22.
8
Survival in Differentiated Thyroid Cancer: Comparing the AJCC Cancer Staging Seventh and Eighth Editions.分化型甲状腺癌的生存:比较 AJCC 癌症分期第七版和第八版。
Thyroid. 2018 Oct;28(10):1301-1310. doi: 10.1089/thy.2017.0572.
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Cancer statistics, 2018.癌症统计数据,2018 年。
CA Cancer J Clin. 2018 Jan;68(1):7-30. doi: 10.3322/caac.21442. Epub 2018 Jan 4.
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Serial Neck Ultrasonographic Evaluation of Changes in Papillary Thyroid Carcinoma During Pregnancy.妊娠期间甲状腺乳头状癌的颈部连续超声评估。
Thyroid. 2017 Jun;27(6):773-777. doi: 10.1089/thy.2016.0618. Epub 2017 May 17.