Scherrer M
Pneumologische Abteilung, Medizinische Universitätsklinik, Inselspital, Bern.
Schweiz Med Wochenschr. 1987 Aug 29;117(35):1307-14.
In 60 patients with advanced COPD, lung function was studied retrospectively at the beginning and end of a 12 to 175 months' test period. 25 patients continued to smoke 5 or more cigarettes daily (smokers). The other 35 patients were ex-smokers or smoked only 1 to 4 cigarettes daily during the trial (non-smokers). In the heavy smoker group FEV1 diminished much more rapidly than in the non-smoking group (p less than 0.01). We observed a significant dose-response ratio between the number of cigarettes smoked and the decrease in FEV1 (r = 0.27, p less than 0.025). No causes other than smoking were found for the fall in FEV1: age, weight, place of residence, profession, sputum evaluation and inhalation therapy were statistically equal in the non-smoking and the smoking group. However, one unexpected result was that more non-smokers had had long term treatment with steroids than smokers. This may mean that non-smokers have better compliance or that there is a subgroup more sensitive to COPD who thus take more steroids and are more inclined to stop smoking than a less sensitive population. The question remains open.
在60例晚期慢性阻塞性肺疾病（COPD）患者中，对12至175个月试验期开始和结束时的肺功能进行了回顾性研究。25例患者继续每天吸烟5支或更多（吸烟者）。另外35例患者为戒烟者或在试验期间每天仅吸1至4支烟（非吸烟者）。在重度吸烟者组中，第一秒用力呼气容积（FEV1）下降速度比非吸烟组快得多（p<0.01）。我们观察到吸烟支数与FEV1下降之间存在显著的剂量反应比（r = 0.27，p<0.025）。除吸烟外，未发现FEV1下降的其他原因：非吸烟组和吸烟组在年龄、体重、居住地点、职业、痰液评估和吸入治疗方面在统计学上无差异。然而，一个意外的结果是，长期接受类固醇治疗的非吸烟者比吸烟者更多。这可能意味着非吸烟者依从性更好，或者存在一个对COPD更敏感的亚组，因此比不那么敏感的人群服用更多的类固醇且更倾向于戒烟。这个问题仍然悬而未决。
