Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an, 710061, Shaanxi, China.
National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, No. 76 West Yanta Road, Xi'an, 710061, Shaanxi, China.
Sci Rep. 2023 Jan 31;13(1):1708. doi: 10.1038/s41598-023-27715-z.
This study aimed to explore the feasibility of the magnetic compression technique (MCT) for ureterovesical anastomosis in a rabbit model with ureteral obstruction. The distal ureteral obstruction model using female New Zealand rabbits was induced by ligating the distal end of the right ureter with silk thread for four weeks. A pair of cylindrical NdFeB magnets (daughter magnet and parent magnet) with a hole in the center was used for the ureterovesical anastomosis. The daughter magnet and the parent magnet were respectively placed close to the obstruction site through the dilated proximal ureter and urethra, and then the daughter-parent magnets pair was attracted together automatically. Postoperative X-rays were taken to confirm the position of the magnets. The anastomotic stoma specimens were obtained two weeks postoperatively, and the anastomotic stoma formation was observed by the naked eye and histological staining. The operation time and the anastomotic burst pressure were measured. The ureter was significantly dilated in the fourth week after ligation, which satisfied the placement of the daughter magnet. The ureterovesical magnet placements were successfully performed in ten experimental rabbits, with an operation time of 36.5 ± 6.09 min. The parent and daughter magnets attracted each other well and were subsequently removed through the urethra two weeks postoperatively, resulting in the establishment of ureterovesical anastomosis. The anastomotic burst pressure was 147.5 ± 14.59 mmHg. Gross specimens and histological examination of the anastomotic stoma showed that the anastomotic stoma healed well. MCT is feasible and simple for ureterovesical anastomosis.
本研究旨在探讨磁压缩技术(MCT)在兔梗阻性输尿管模型中进行输尿管膀胱吻合术的可行性。通过丝线结扎右侧输尿管末端 4 周,诱导产生远端输尿管梗阻模型。使用一对带有中心孔的圆柱形 NdFeB 磁铁(子磁体和母磁体)进行输尿管膀胱吻合术。将子磁体和母磁体分别通过扩张的近端输尿管和尿道放置在梗阻部位附近,然后自动吸引子-母磁体对。术后进行 X 射线检查以确认磁铁的位置。术后 2 周取出吻合口标本,肉眼观察和组织学染色观察吻合口形成情况。测量手术时间和吻合口爆裂压。结扎后第 4 周输尿管明显扩张,满足子磁体的放置要求。在 10 只实验兔中成功进行了输尿管膀胱磁体放置,手术时间为 36.5±6.09 分钟。母磁体和子磁体相互吸引良好,术后 2 周通过尿道取出,从而建立了输尿管膀胱吻合。吻合口爆裂压为 147.5±14.59mmHg。吻合口的大体标本和组织学检查显示吻合口愈合良好。MCT 是一种可行且简单的输尿管膀胱吻合术方法。