Martín-Merchán Andrea, Moro Belen, Bouet Antoine, Bologna Nicolas G
Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Bellaterra, Barcelona 08193, Spain.
J Exp Bot. 2023 Apr 9;74(7):2374-2388. doi: 10.1093/jxb/erad030.
ARGONAUTE (AGO) proteins are the final effectors of small RNA-mediated transcriptional and post-transcriptional silencing pathways. Plant AGO proteins are essential for preserving genome integrity, regulating developmental processes, and in stress responses and pathogen defense. Since the discovery of the first eukaryotic AGO in Arabidopsis, our understanding of these proteins has grown exponentially throughout all the eukaryotes. However, many aspects of AGO proteins' modes of action and how they are influenced by their subcellular localization are still to be elucidated. Here, we provide an updated and comprehensive view of the evolution, domain architecture and roles, expression pattern, subcellular localization, and biological functions of the 10 AGO proteins in Arabidopsis.
AGO（AGO）蛋白是小RNA介导的转录和转录后沉默途径的最终效应因子。植物AGO蛋白对于维持基因组完整性、调节发育过程以及应激反应和病原体防御至关重要。自拟南芥中首次发现真核AGO蛋白以来，我们对这些蛋白的了解在所有真核生物中呈指数级增长。然而，AGO蛋白的作用模式及其如何受亚细胞定位影响的许多方面仍有待阐明。在这里，我们提供了关于拟南芥中10种AGO蛋白的进化、结构域结构和作用、表达模式、亚细胞定位及生物学功能的最新全面观点。
