Department of Perinatal Medicine, Mercy Hospital for Women, Heidelberg, Victoria, Australia.
Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.
Aust N Z J Obstet Gynaecol. 2023 Jun;63(3):454-459. doi: 10.1111/ajo.13645. Epub 2023 Feb 1.
Little is published on cytomegalovirus (CMV) serological screening at the first antenatal visit or the contemporary CMV seroprevalence rates among the Australian pregnant population. We performed a retrospective analysis of public hospital births in a major tertiary centre (n = 840) over a two month period. We found that 13.6% (95% confidence interval (CI) 11.4-16.1%) of women had been screened for CMV at their first antenatal visit with their general practitioner. Of these, 43.0% (95% CI 34.3-52.1%) were CMV seronegative and therefore susceptible to primary infection. Seronegative women were also more likely to have been born in an economically developed country, to live in a socio-economically advantaged postcode and to be nulliparous. The information from this study may help guide future studies of congenital CMV risk reduction strategies.
关于巨细胞病毒（CMV）在初次产前检查时的血清学筛查，以及澳大利亚孕妇人群中 CMV 的现患率，相关文献报道较少。我们对一个主要的三级中心（n=840）在两个月的时间内的公立医院分娩进行了回顾性分析。我们发现，13.6%（95%置信区间[CI]为 11.4-16.1%）的女性在其第一次产前就诊时曾由全科医生筛查 CMV。其中，43.0%（95%CI 为 34.3-52.1%）为 CMV 血清阴性，因此易受原发感染。血清阴性的女性更有可能出生在经济发达国家，居住在社会经济地位较高的邮区，且为初产妇。本研究的信息可能有助于指导未来关于降低先天性 CMV 风险的策略的研究。
