利用分子转子探针追踪铁死亡和自噬过程中的内质网黏度。
Tracking endoplasmic reticulum viscosity during ferroptosis and autophagy using a molecular rotor probe.
机构信息
Bionanotechonlogy Lab, Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhauri, Bhopal 462 066, Madhya Pradesh, India.
出版信息
Chem Commun (Camb). 2023 Feb 9;59(13):1769-1772. doi: 10.1039/d2cc06146e.
Ferroptosis is a unique non-apoptotic cell death process associated with endoplasmic reticulum (ER) stress-related diseases. We have designed and synthesized a far-red emitting and ER targetable viscosity-sensitive fluorophore to track ER-phagy. Furthermore, the ER viscosity alteration during the ferroptosis process was investigated intensity and lifetime-based spectroscopy and microscopy.
铁死亡是一种独特的非凋亡性细胞死亡过程，与内质网（ER）应激相关疾病有关。我们设计并合成了一种远红色发射且靶向内质网的粘度敏感荧光探针，以追踪内质网自噬。此外，还通过基于强度和寿命的光谱和显微镜研究了铁死亡过程中 ER 粘度的变化。
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