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纳米抗生素在感染性疾病诊治中的应用。

Application of nano-antibiotics in the diagnosis and treatment of infectious diseases.

机构信息

Al-Mustaqbal University College, Department of Radiological Techniques, Hillah, Babylon, Iraq.

University of Babylon, College of Science, Department of Chemistry, Babylon, Babylon, Iraq.

出版信息

Braz J Biol. 2023 Jan 30;84:e264946. doi: 10.1590/1519-6984.264946. eCollection 2023.

Abstract

Infectious diseases are the leading cause of death worldwide. Thus, nanotechnology provides an excellent opportunity to treat drug-resistant microbial infections. Numerous antibiotics have been used to inhibit the growth and kill of microbes, but the development of resistance and the emergence of side effects have severely limited the use of these agents. Due to the development of the nanotechnology, nanoparticles are widely used as antimicrobials. Silver and chitosan nanoparticles have antifungal, antiviral and antibacterial properties, and many studies confirm the antifungal properties of silver nanoparticles. Nowadays, the use of nanoparticles in the diagnosis and treatment of infectious diseases has developed due to less side effects and also the help of these particles in effective drug delivery to the target tissue. Liposomes are also used as carriers of drug delivery, genes, and modeling of cell membranes in both animals and humans. The ability of these liposomes to encapsulate large amounts of drugs, minimize unwanted side effects, high effectiveness and low toxicity has attracted the interest of researchers. This review article examines recent efforts by researchers to identify and treat infectious diseases using antimicrobial nanoparticles and drug nano-carriers.

摘要

传染病是全球死亡的主要原因。因此,纳米技术为治疗耐药性微生物感染提供了极好的机会。已经有许多抗生素被用于抑制微生物的生长和杀灭,但耐药性的发展和副作用的出现严重限制了这些药物的使用。由于纳米技术的发展,纳米颗粒被广泛用作抗菌剂。银和壳聚糖纳米颗粒具有抗真菌、抗病毒和抗菌特性,许多研究证实了银纳米颗粒的抗真菌特性。如今,由于副作用较少,以及这些颗粒在将药物有效递送到靶组织方面的帮助,纳米颗粒在传染病的诊断和治疗中的应用得到了发展。脂质体也被用作药物递送、基因载体和动物及人类细胞膜建模的载体。这些脂质体能够包裹大量药物、最小化不必要的副作用、提高有效性和降低毒性,这引起了研究人员的兴趣。本文综述了研究人员最近在使用抗菌纳米颗粒和药物纳米载体来识别和治疗传染病方面的努力。

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