Franci Gianluigi, Falanga Annarita, Galdiero Stefania, Palomba Luciana, Rai Mahendra, Morelli Giancarlo, Galdiero Massimiliano
Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università degli Studi di Napoli, Vico L. De Crecchio 7, 80138 Napoli, Italy.
Department of Pharmacy, University of Naples Federico II, 80100 Naples, Italy.
Molecules. 2015 May 18;20(5):8856-74. doi: 10.3390/molecules20058856.
Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. Advances in nanotechnology have opened new horizons in nanomedicine, allowing the synthesis of nanoparticles that can be assembled into complex architectures. Novel studies and technologies are devoted to understanding the mechanisms of disease for the design of new drugs, but unfortunately infectious diseases continue to be a major health burden worldwide. Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and control of disparate infections. Currently nanotechnology and nanomaterials are fully integrated in common applications and objects that we use every day. In addition, the silver nanoparticles are attracting much interest because of their potent antibacterial activity. Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. This review aims to summarize the emerging efforts to address current challenges and solutions in the treatment of infectious diseases, particularly the use of nanosilver antimicrobials.
多重耐药性在传染病治疗中是一个日益严重的问题，广谱抗生素的广泛使用已使许多人类细菌病原体产生了抗生素耐药性。纳米技术的进步为纳米医学开辟了新视野，使得能够合成可组装成复杂结构的纳米颗粒。新的研究和技术致力于了解疾病机制以设计新药，但遗憾的是，传染病仍是全球主要的健康负担。自古以来，银就因其抗菌作用而闻名，几个世纪以来一直用于预防和控制各种感染。目前，纳米技术和纳米材料已完全融入我们日常使用的普通应用和物品中。此外，银纳米颗粒因其强大的抗菌活性而备受关注。许多研究还表明银纳米颗粒对细菌生物膜具有重要活性。本综述旨在总结为应对传染病治疗中的当前挑战和解决方案所做出的新努力，特别是纳米银抗菌剂的使用。
