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膨润土和 l-半胱氨酸修饰的碳糊电极用于同时测定抗坏血酸和尿酸：在生物流体中的应用。

A Carbon Paste Electrode Modified by Bentonite and l-Cysteine for Simultaneous Determination of Ascorbic and Uric Acids: Application in Biological Fluids.

机构信息

Laboratory of Materials and Interfacial Systems, Faculty of Science, Abdelmalek Essaadi University, B.P. 2121, 93002, Tetouan, Morocco.

Laboratory of Information System and Software Engineering, National School of Applied Sciences of Tetouan, Abdelmalek Essaadi University, 93000, Tetouan, Morocco.

出版信息

ChemistryOpen. 2023 Feb;12(2):e202200201. doi: 10.1002/open.202200201.

DOI:10.1002/open.202200201
PMID:36722827
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9891123/
Abstract

A novel modification of a paste carbon electrode by Bentonite (Bent) and l-Cysteine (l-Cyst) was carried out for uric acid (UA) and ascorbic acid (AA) detection and quantification. Morphological and compositional characterization of the electrode surface were carried out using electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopic analysis (EDS). Cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques were used to analyze UA and AA. The obtained sensor shows a good stability, sensibility, selectivity, and regeneration ability. Accordingly, the limit of detection (LOD) is found to be 0.031 μm and 9.6 μm for UA and AA, respectively. A good linearity in the range of 0.1 to 100 μm for UA and 10 to 1000 μm for AA was obtained. The peak-to-peak separation of UA-AA (ΔE ) was determined to be 330 mV. In addition, the sensor is applied successfully to monitor UA and AA in serum samples.

摘要

一种新型的糊碳电极，通过膨润土（Bent）和 l-半胱氨酸（l-Cyst）进行修饰，用于尿酸（UA）和抗坏血酸（AA）的检测和定量。使用电化学阻抗谱（EIS）、扫描电子显微镜（SEM）和能量色散 X 射线光谱分析（EDS）对电极表面的形貌和组成进行了表征。采用循环伏安法（CV）和方波伏安法（SWV）技术分析 UA 和 AA。所得传感器具有良好的稳定性、灵敏度、选择性和再生能力。因此，UA 和 AA 的检测限（LOD）分别为 0.031 μm 和 9.6 μm。UA 的线性范围为 0.1 至 100 μm，AA 的线性范围为 10 至 1000 μm。UA-AA 的峰-峰分离（ΔE）为 330 mV。此外，该传感器成功地应用于血清样品中 UA 和 AA 的监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/6fecf815971b/OPEN-12-e202200201-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/bf8542815478/OPEN-12-e202200201-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/4bf7cddfceae/OPEN-12-e202200201-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/3daa28e26405/OPEN-12-e202200201-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/f109dc437267/OPEN-12-e202200201-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/95bb6f132049/OPEN-12-e202200201-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/f3d387676cf5/OPEN-12-e202200201-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/6edc4c79ed4c/OPEN-12-e202200201-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/476c13c35b5d/OPEN-12-e202200201-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7484/9891123/59f1afec9924/OPEN-12-e202200201-g003.jpg
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