牛奶外泌体：一种具有巨大应用潜力的口服给药系统。

Milk exosomes: an oral drug delivery system with great application potential.

作者信息

Tian Meng-Yuan, Hao Dong-Xia, Liu Yang, He Jin, Zhao Zhuo-Hua, Guo Ting-Yu, Li Xing, Zhang Yuan

机构信息

Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry (Shaanxi Normal University), The Ministry of Education; National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China; College of Life Sciences, Shaanxi Normal University, Xi'an, China.

The International Department of the High School Affiliated to Shaanxi Normal University, Xi'an, China.

出版信息

Food Funct. 2023 Feb 6;14(3):1320-1337. doi: 10.1039/d2fo02013k.

DOI:10.1039/d2fo02013k

PMID:36722924

Abstract

Exosomes are extracellular vesicles with the smallest diameter, usually divided into cellular sources and body fluid sources. Due to their special properties different from cell-derived exosomes, the application of milk exosomes as an oral drug delivery system has increased greatly. This article introduces the physical and chemical properties of exosomes, separation technology, dyeing and labeling technology, targeted modification technology, and the application of milk exosomes in drug loading and disease therapies.

摘要

外泌体是直径最小的细胞外囊泡，通常分为细胞来源和体液来源。由于其具有不同于细胞来源外泌体的特殊性质，牛奶外泌体作为口服药物递送系统的应用已大幅增加。本文介绍了外泌体的物理化学性质、分离技术、染色与标记技术、靶向修饰技术，以及牛奶外泌体在药物装载和疾病治疗中的应用。