Zhu Bengao, Zhang Mengmeng, Chen Qiang, Li Zeke, Chen Senbin, Zhu Jintao
State Key Laboratory of Materials Processing and Mold Technology, and Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education (HUST), School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, Hubei, PR China.
Biomater Sci. 2023 Mar 14;11(6):2129-2138. doi: 10.1039/d2bm01944b.
Chemodynamic therapy (CDT) reflects a novel reactive oxygen species (ROS)-related cancer therapeutic approach. However, CDT monotherapy is often limited by weak efficacy and insufficient endogenous HO. Herein, a multifunctional combined bioreactor (MnFe-LDH/MTX@GOx@Ta, MMGT) relying on MnFe-layered double hydroxide (MnFe-LDH) loaded with methotrexate (MTX) and coated with glucose oxidase (GOx)/tannin acid (Ta) is established for applications in HO self-supply and photothermal enhanced chemo/chemodynamic combined therapy along with photothermal (PT) /magnetic resonance (MR) dual-modality imaging ability for cancer treatment. Once internalized into tumor cells, MMGT achieves starvation therapy by catalyzing the oxidation of glucose with GOx, accompanied by the regeneration of HO, enabling a Fenton-like reaction to accomplish GOx catalytic amplified CDT. Moreover, MMGT manifests significant tumor-killing ability through improved CDT performance with outstanding photothermal conversion efficiency ( = 52.2%) under 808 nm laser irradiation. In addition, the release of Mn from MnFe-LDH in a solid tumor can significantly enhance -contrast MR imaging signals. Combined with MnFe-LDH-induced PT imaging under 808 nm laser irradiation, a dual-modality imaging directed theranostic nanoplatform has been developed. The present study provides a new strategy to design HO self-supply and ROS evolving NIR light-absorption theranostic nanoagent for highly efficient and combined chemo/chemodynamic cancer treatment.
化学动力学疗法（CDT）是一种新型的与活性氧（ROS）相关的癌症治疗方法。然而，CDT单一疗法往往受到疗效不佳和内源性过氧化氢不足的限制。在此，我们构建了一种多功能组合生物反应器（MnFe-LDH/MTX@GOx@Ta，MMGT），它依赖于负载甲氨蝶呤（MTX）并包覆葡萄糖氧化酶（GOx）/单宁酸（Ta）的MnFe层状双氢氧化物（MnFe-LDH），用于在癌症治疗中实现过氧化氢的自我供应、光热增强化疗/化学动力学联合治疗以及光热（PT）/磁共振（MR）双模态成像。一旦MMGT内化进入肿瘤细胞，它通过GOx催化葡萄糖氧化实现饥饿疗法，同时伴随着过氧化氢的再生，从而使类芬顿反应完成GOx催化放大的CDT。此外，MMGT在808 nm激光照射下具有出色的光热转换效率（ = 52.2%），通过改善CDT性能表现出显著的肿瘤杀伤能力。此外，实体瘤中MnFe-LDH释放的Mn可显著增强T2加权磁共振成像信号。结合808 nm激光照射下MnFe-LDH诱导的光热成像，开发了一种双模态成像引导的治疗诊断纳米平台。本研究为设计用于高效联合化疗/化学动力学癌症治疗的过氧化氢自我供应和ROS产生的近红外光吸收治疗诊断纳米剂提供了一种新策略。
