肿瘤微环境中的免疫细胞代谢。

Metabolism of Immune Cells in the Tumor Microenvironment.

机构信息

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Department of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

Adv Exp Med Biol. 2021;1311:173-185. doi: 10.1007/978-3-030-65768-0_13.

DOI:10.1007/978-3-030-65768-0_13

PMID:34014543

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9703210/

Abstract

The tumor microenvironment (TME) is a complex biological structure surrounding tumor cells and includes blood vessels, immune cells, fibroblasts, adipocytes, and extracellular matrix (ECM) [1, 2]. These heterogeneous surrounding structures provide nutrients, metabolites, and signaling molecules to provide a cancer-friendly environment. The metabolic interplay between immune cells and cancer cells in the TME is a key feature not only for understanding tumor biology but also for discovering cancer cells' vulnerability. As cancer immunotherapy to treat cancer patients and the use of metabolomics technologies become more and more common [3], the importance of the interplay between cancer cells and immune cells in the TME is emerging with respect to not only cell-to-cell interactions but also metabolic pathways. This interaction between immune cells and cancer cells is a complex and dynamic process in which immune cells act as a determinant factor of cancer cells' fate and vice versa. In this chapter, we provide an overview of the metabolic interplay between immune cells and cancer cells and discuss the therapeutic opportunities as a result of this interplay in order to define targets for cancer treatment. It is important to understand and identify therapeutic targets that interrupt this cancerpromoting relationship between cancer cells and the surrounding immune cells, allowing for maximum efficacy of immune checkpoint inhibitors as well as other genetic and cellular therapies.

摘要

肿瘤微环境（TME）是围绕肿瘤细胞的复杂生物结构，包括血管、免疫细胞、成纤维细胞、脂肪细胞和细胞外基质（ECM）[1,2]。这些异质的周围结构为肿瘤提供了营养物质、代谢物和信号分子，以提供一个有利于癌症的环境。TME 中免疫细胞和癌细胞之间的代谢相互作用不仅是理解肿瘤生物学的关键特征，也是发现癌细胞脆弱性的关键特征。随着癌症免疫疗法治疗癌症患者和代谢组学技术的应用越来越普遍[3]，TME 中癌细胞和免疫细胞之间的相互作用的重要性不仅体现在细胞间相互作用，还体现在代谢途径方面。免疫细胞和癌细胞之间的这种相互作用是一个复杂和动态的过程，其中免疫细胞作为癌细胞命运的决定因素，反之亦然。在本章中，我们概述了免疫细胞和癌细胞之间的代谢相互作用，并讨论了由此相互作用产生的治疗机会，以确定癌症治疗的靶点。了解和识别中断癌细胞与周围免疫细胞之间这种促进癌症关系的治疗靶点对于最大限度地提高免疫检查点抑制剂以及其他遗传和细胞疗法的疗效非常重要。