来自匙叶金丝桃的两对间苯三酚对映体及其立体化学结构
[Two pairs of phloroglucinol enantiomers from Hypericum wightianum and their stereochemical structures].
作者信息
Zhang Rui-Fei, Fan Yan-Xiao, Ji Yuan-Yuan, Long Chun-Lin
机构信息
Key Laboratory of Ecology and Environment in Minority Areas (Minzu University of China) National Ethnic Affairs Commission Beijing 100081, China College of Life and Environmental Sciences, Minzu University of China Beijing 100081, China.
Key Laboratory of Ecology and Environment in Minority Areas (Minzu University of China) National Ethnic Affairs Commission Beijing 100081, China College of Life and Environmental Sciences, Minzu University of China Beijing 100081, China Key Laboratory of Ethnomedicine (Minzu University of China), Ministry of Education Beijing 100081, China Key Laboratory of Mass Spectrometry Imaging and Metabolomics (Minzu University of China) National Ethnic Affairs Commission Beijing 100081, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2023 Jan;48(2):421-429. doi: 10.19540/j.cnki.cjcmm.20220612.202.
The chemical constituents in the ethanol extract of Hypericum wightianum(Hypericaceae) were purified by column chromatography and identified via magnetic resonance imaging(NMR), high-resolution mass spectrum, and circular dichroism. A total of 22 compounds were identified, including eight polyprenylated phloroglucinols(1-8), three chromones(9-11), and three terpenoids(14-16) and so on. Among them, compounds 16 and 17 were first reported in the genus Hypericum, and compounds 1-11, 14, 15, and 19 were first isolated from H. wightianum. Compounds 1-4 were previously reported as two pairs of enantiomers. This study reported the chiral resolutions and absolute configurations of compounds 1-4 for the first time.
通过柱色谱法对金丝桃科植物湿地金丝桃乙醇提取物中的化学成分进行纯化，并通过磁共振成像（NMR）、高分辨率质谱和圆二色光谱进行鉴定。共鉴定出22种化合物，包括8种多异戊烯基间苯三酚（1-8）、3种色酮（9-11）、3种萜类化合物（14-16）等。其中，化合物16和17首次在金丝桃属中报道，化合物1-11、14、15和19首次从湿地金丝桃中分离得到。化合物1-4之前报道为两对对映体。本研究首次报道了化合物1-4的手性拆分和绝对构型。
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