中药通过调节肠道微生物群缓解溃疡性结肠炎。
Traditional Chinese Medicine Alleviates Ulcerative Colitis via Modulating Gut Microbiota.
作者信息
Feng Wan, Zhu Lei, Shen Hong
机构信息
Department of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
出版信息
Evid Based Complement Alternat Med. 2022 Mar 9;2022:8075344. doi: 10.1155/2022/8075344. eCollection 2022.
Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disorder characterized by relapsing and remitting inflammation of the bowel. In recent decades, traditional Chinese medicine (TCM) has been widely used in the therapy of UC. However, its underlying mechanisms have not been sufficiently elucidated. Accumulating studies indicate that the gut microbial dysbiosis is closely related to UC. It has been demonstrated that TCM could alter the composition of intestinal microbiota by enriching beneficial and SCFA-producing bacteria and reducing pathogenic bacteria. In this review, we discussed recent evidence regarding the TCM and its role in modulating gut microbiota for the treatment of UC.
摘要
溃疡性结肠炎（UC）是一种慢性炎症性肠病，其特征为肠道炎症反复发作和缓解。近几十年来，中医已广泛应用于UC的治疗。然而，其潜在机制尚未得到充分阐明。越来越多的研究表明，肠道微生物群失调与UC密切相关。已经证明，中医可以通过富集有益菌和产生短链脂肪酸的细菌以及减少病原菌来改变肠道微生物群的组成。在这篇综述中，我们讨论了有关中医及其在调节肠道微生物群以治疗UC方面作用的最新证据。
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